MxA gene expression in juvenile dermatomyositis peripheral blood mononuclear cells: Association with muscle involvement

Kevin A. O'Connor*, Kathy A. Abbott, Brad Sabin, Maxine Kuroda, Lauren M. Pachman

*Corresponding author for this work

Research output: Contribution to journalArticle

51 Scopus citations

Abstract

Juvenile dermatomyositis (JDM), a systemic vasculopathy, is characterized by inflammation of skin and muscle. Muscle biopsies from untreated JDM patients show upregulation of type I interferon (IFN)-inducible genes, including myxovirus resistance protein A (MxA). The present study examines whether MxA mRNA expression in peripheral blood mononuclear cells (PBMC) from JDM patients: (1) is elevated compared to healthy controls, (2) reflects disease activity, and (3) changes with the onset of clinically effective treatment. MxA mRNA expression in JDM PBMC obtained at the initial clinic visit was elevated compared to controls and was positively correlated with Disease Activity Score (DAS) for muscle, but not with DAS for skin, suggesting that damage to skin and muscle in JDM may each have a discrete pathophysiology. During the course of clinically effective treatment, decrease in muscle symptoms was associated with a decrease in PBMC MxA mRNA expression.

Original languageEnglish (US)
Pages (from-to)319-325
Number of pages7
JournalClinical Immunology
Volume120
Issue number3
DOIs
StatePublished - Sep 2006

Keywords

  • Interferon
  • Juvenile dermatomyositis
  • Muscle
  • MxA
  • PBMC

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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