Mycobacterium avium-intracellulare Infection Associated With Hairy-cell Leukemia

Paul D L Maurice, Christopher Bunker, Frank Giles, Anthony Goldstone, John Holton

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


A 66-year-old man with hairy-cell leukemia was treated successfully with interferon alfa, with normalization of his hematologic parameters. After 2.5 months he became ill again and, following extensive investigation, Mycobacterium avium-intracellulare grew from a bone marrow specimen. Although initiation of quadruple antituberculous chemotherapy resulted in an improvement of his general condition, after two months he started to develop widespread cutaneous and subcutaneous nodules, biopsy of which showed appearances compatible with mycobacterial infection. Over the next two months the skin lesions progressed slowly so erythromycin, to which in vitro testing showed the organism to be sensitive, was added to his therapy. This resulted in a marked improvement of all skin lesions. This case is the first to be reported of disseminated atypical mycobacterial infection in a patient receiving interferon treatment for hairy-cell leukemia. (Arch Dermatol 1988;124:1545-1549).

Original languageEnglish (US)
Pages (from-to)1545-1549
Number of pages5
JournalArchives of dermatology
Issue number10
StatePublished - Oct 1988

ASJC Scopus subject areas

  • Dermatology

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