Mycosis fungoides and the Sezary syndrome: A review of pathogenesis, diagnosis, and therapy

T. M. Kuzel*, H. H. Roenigk, S. T. Rosen

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

125 Scopus citations


Mycosis fungoides (MF) and the Sezary syndrome (SS) are non-Hodgkin's lymphomas with a T-cell phenotype, which have cutaneous involvement as their predominant feature. These disorders are becoming more common, and the patients are frequently being referred to medical oncologists for assistance in management. The development of advanced laboratory techniques, such as molecular genetics and cell-surface phenotyping, has greatly enhanced our understanding of their pathogenesis and may lead to identification of responsible etiologic factors. A myriad of treatment options have been investigated including topical approaches, systemic chemotherapy, and external radiation. Currently, extensive trials are underway examining the potential benefits of agents such as the interferons, interleukin-2, monoclonal antibodies, the retinoids, 2-chlorodeoxyadenosine, and other novel biologic response modifiers or chemotherapeutics. Although all these therapies have benefit in phase II trials, few randomized comparative trials have been performed to identify optimal therapies. Performance of such trials should now become a priority.

Original languageEnglish (US)
Pages (from-to)1298-1313
Number of pages16
JournalJournal of Clinical Oncology
Issue number7
StatePublished - Jan 1 1991

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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