Mycotoxin induction of somatic mosaicism in Drosophila and DNA repair in mammalian liver cell cultures

Gennady A. Belitsky*, Elizabeth M. Khovanova, Irene V. Budunova, Helen G. Sharuptis

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Thegenotoxic activity of four mycotoxins has been studied. A high level of somatic mutagenesis in imaginal disks of Drosophila melanogaster larvae and DNA repair synthesis in human embryo and adult rat liver cell cultures was induced only by the strong carcinogen aflatoxin B1. Patulin somewhat elevated the level of somatic mutations in D. melanogaster, but did not elicit DNA repair synthesis. Citrinin and stachybotryotoxin were inactive in both systems.

Original languageEnglish (US)
Pages (from-to)133-143
Number of pages11
JournalCell Biology and Toxicology
Volume1
Issue number3
DOIs
StatePublished - Jun 1 1985

Keywords

  • D. melanogaster
  • DNA repair
  • hepatocytes
  • mycotoxins
  • somatic mutagenesis

ASJC Scopus subject areas

  • Toxicology
  • Cell Biology
  • Health, Toxicology and Mutagenesis

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