The genotoxic activity of four mycotoxins has been studied. High level of somatic mutagenesis in imaginal discs of Drosophila melanogaster larvae and DNA repair synthesis in human embryo and adult rat liver cell cultures were inducible only by highly cancerogenous aflatoxin B1. Patulin, a weak direct-action carcinogenous substance, slightly elevated the mutagenesis in somatic cells of Drosophila but did not induce DNA repair synthesis in liver cell cultures. Citrinin that did not exhibit any carcinogenous properties when used alone and stachybotrotoxin with non-reported carcinogenous activity appeared inactive in the test-systems applied. The possibilities of rapid recognition of carcinogenous mycotoxins by detecting their genotoxic properties are discussed.
|Original language||English (US)|
|Number of pages||4|
|Journal||Byulleten Eksperimentalnoi Biologii i Meditsiny|
|State||Published - 1983|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)