Myelin-associated glycoprotein and myelin galactolipids stabilize developing axo-glial interactions

Jill Marcus, Jeffrey L. Dupree, Brian Popko*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

91 Scopus citations

Abstract

We have analyzed mice that lack both the myelin-associated glycoprotein (MAG) and the myelin galactolipids, two glial components implicated in mediating axo-glial interactions during the myelination process. The single-mutant mice produce abnormal myelin containing similar ultrastructural abnormalities, suggesting that these molecules may play an overlapping role in myelin formation. Furthermore, the absence of the galactolipids results in a disruption in paranodal axo-glial interactions, and we show here that similar, albeit less severe, abnormalities exist in the developing MAG mutant. In the double-mutant mice, maintenance of axo-glial adhesion is significantly more affected than in the single mutants, supporting the overlapping function hypothesis. We also show that independently of MAG, galactolipids, and paranodal junctional components, immature nodes of Ranvier form normally, but rapidly destabilize in their absence. These data indicate that distinct molecular mechanisms are responsible for the formation and maintenance of axo-glial interactions.

Original languageEnglish (US)
Pages (from-to)567-577
Number of pages11
JournalJournal of Cell Biology
Volume156
Issue number3
DOIs
StatePublished - Feb 4 2002

Keywords

  • Galactolipids
  • MAG
  • Myelination
  • Nodes
  • Periaxon

ASJC Scopus subject areas

  • Cell Biology

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