Myeloid Neoplasms with Germline Predisposition. A New Provisional Entity Within the World Health Organization Classification.

David R. Czuchlewski*, Lo Ann C. Peterson

*Corresponding author for this work

Research output: Contribution to journalReview article

9 Scopus citations

Abstract

The forthcoming update of the World Health Organization (WHO) classification of hematopoietic neoplasms will feature "Myeloid Neoplasms with Germline Predisposition" as a new provisional diagnostic entity. This designation will be applied to some cases of acute myeloid leukemia and myelodysplastic syndrome arising in the setting of constitutional mutations that render patients susceptible to the development of myeloid malignancies. For the diagnostic pathologist, recognizing these cases and confirming the diagnosis will demand a sophisticated grasp of clinical genetics and molecular techniques. This article presents a concise review of this new provisional WHO entity, including strategies for clinical practice.

Original languageEnglish (US)
Pages (from-to)165-176
Number of pages12
JournalSurgical Pathology Clinics
Volume9
Issue number1
DOIs
StatePublished - Mar 1 2016

Keywords

  • Acute myeloid leukemia
  • Familial cancer
  • Germline predisposition mutation
  • Myelodysplastic syndrome

ASJC Scopus subject areas

  • Surgery
  • Pathology and Forensic Medicine

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