Myeloma management guidelines: A consensus report from the Scientific Advisors of the International Myeloma Foundation

Brian G.M. Durie*, Robert A. Kyle, Andrew Belch, William Bensinger, Joan Blade, Mario Boccadoro, J. Anthony Child, Raymond Comenzo, Ben Djulbegovic, Dorotea Fantl, Gosta Gahrton, Jean Luc Harousseau, Vania Hungria, Douglas Joshua, Heinz Ludwig, Jayesh Mehta, Angelina Rodrique Morales, Gareth Morgan, Amara Nouel, Martin OkenRaymond Powles, David Roodman, Jesus San Miquel, Kazuyuki Shimizu, Seema Singhal, Bhawna Sirohi, Pieter Sonneveld, Guido Tricot, Brian Van Ness

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

373 Scopus citations


These consensus guidelines have been compiled with input from the Scientific Advisors of the International Myeloma Foundation. Their production involved several steps including: • A 3-day Scientific Advisors meeting, during which each specific area was presented and discussed (May 2002). • Review of key literature, especially randomized study results, but also Medline, Internet, Cochrane database searches, and prior guidelines (Br J Haematol 115: 522-540, 2001). • Feedback from patients participating in the International Myeloma Foundation, patient programs. These guidelines encompass both the published literature and expert opinions. Recommendations based upon expert opinions are identified as such. The intent is for the guidelines to be international in scope, plus provide recommendations for both clinical practice and research approaches. 'Consensus' reflects general, although not necessarily unanimous, agreement. Details are discussed as appropriate. For convenience, the recommendations are divided into: 1 Diagnostic criteria. 2 Staging and prognostic factors. 3 Frontline therapy. 4 High-dose therapy and transplant. 5 Maintenance therapy. 6 Supportive care and management of specific complications. 7 Novel therapies and new technologies.

Original languageEnglish (US)
Pages (from-to)379-398
Number of pages20
JournalHematology Journal
Issue number6
StatePublished - 2003


  • Consensus
  • Guidelines
  • International myeloma foundation
  • Management
  • Multiple myeloma
  • Myeloma

ASJC Scopus subject areas

  • Hematology


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