Myocardial compliance was not altered after acute induction of atrial fibrillation in sheep

Masami Takagaki*, Patrick M. McCarthy, Masahiro Inoue, Mina Chung, Jason T. Connor, Raymond Dessoffy, Yoshie Ochiai, Michael Howard, Kazuyoshi Doi, Michael Kopcak, Todor N. Mazgalev, Kiyotaka Fukamachi

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Background: Although left ventricular (LV) contractility in atrial fibrillation (Af) is known to change in a beat-to-beat fashion, little is known about the changes in LV compliance in Af. Material/Methods: We experimentally induced tachycardic Af (average heart rate - 154 beats per minute) in 18 sheep. LV volume and pressure were simultaneously monitored using a conductance catheter. LV end-diastolic volume (VED) and pressure (PED) were plotted in a beat-to-beat fashion and fitted to the following exponential equation (PED=γ × eβ × VED) in each animal. A random effects model was constructed to determine if the intercepts and slopes differ. Results: In all animals, those plots after the induction of Af fit quite well to the exponential function (r=0.834±0.184) by gating short preceding interval (RR1) beats. By simply taking the natural logarithm of both sides in the equation, the linear relationship (ln(PED) =α + β × VED, where α = lnγ) was observed in all animals before (normal sinus rhythm, NSR) and after the induction of Af. Only two of 18 intercepts and four of 18 slopes deviate between NSR and Af. Most interestingly, the random effects model clearly detailed that the average animal had intercepts and slopes that were not discernibly different between NSR and Af. Conclusions: Unlike LV contractility, myocardial compliance did not change after the acute induction of Af. These interesting results may give us insights into the understanding of the physiology in acute rapid Af.

Original languageEnglish (US)
Pages (from-to)BR147-BR153
JournalMedical Science Monitor
Issue number6
StatePublished - Jun 2005


  • Atrial fibrillation
  • End-diastolic pressure-volume relation
  • Load-independent
  • Sheep

ASJC Scopus subject areas

  • Medicine(all)


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