Myocardial T2-mapping and velocity mapping: Changes in regional left ventricular structure and function after heart transplantation

Michael Markl*, Rahul Rustogi, Mauricio Galizia, Amita Goyal, Jeremy Collins, Asad Usman, Bernd Jung, Daniela Foell, James Carr

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


Monitoring post cardiac transplant (TX) status relies on frequent invasive techniques such as endomyocardial biopsies and right heart cardiac catheterization. The aim of this study was to noninvasively evaluate regional myocardial structure, function, and dyssynchrony in TX patients. Myocardial T2-mapping and myocardial velocity mapping of the left ventricle (basal, midventricular, and apical short-axis locations) was applied in 10 patients after cardiac transplantation (49 ± 13years, n = 2 with signs of mild rejection, time between TX and MRI = 1-64 months) and compared to healthy controls (n = 20 for myocardial velocity mapping and n = 14 for T2). Segmental analysis based on the 16-segment American Heart Association model revealed increased T2 (P = 0.0003) and significant (P < 0.0001) reductions in systolic and diastolic radial and long-axis peak myocardial velocities in TX patients without signs of rejection compared to controls. Multiple comparisons of individual left ventricular segments demonstrated reductions of long-axis peak velocities in 50% of segments (P < 0.001) while segmental T2 values were not significantly different. Systolic radial as well as diastolic radial and long-axis dyssynchrony were significantly (P < 0.04) increased in TX patients indicating less coordinated contraction, expansion, and lengthening. Correlation analysis revealed moderate but significant (P < 0.010) inverse relationships between myocardial T2 and long-axis peak velocities suggesting a structure-function relationship between altered T2 and myocardial function.

Original languageEnglish (US)
Pages (from-to)517-526
Number of pages10
JournalMagnetic resonance in medicine
Issue number2
StatePublished - Aug 2013


  • T2
  • cardiac MRI
  • heart transplant
  • myocardial velocities

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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