Myocardial tissue characterization by gadolinium-enhanced cardiac magnetic resonance imaging for risk stratification of adverse events in hypertrophic cardiomyopathy

Nisha Raiker*, Sirish Vullaganti, Jeremy D Collins, Bradley D. Allen, Lubna Choudhury

*Corresponding author for this work

Research output: Contribution to journalReview article

Abstract

Hypertrophic cardiomyopathy (HCM) is a genetic cardiomyopathy with a wide spectrum of clinical manifestations. Patients can be asymptomatic or suffer major adverse events including sudden cardiac death, ventricular arrhythmias, and heart failure. Identification of individuals with HCM who are at risk for these complications remains challenging. While echocardiography remains the mainstay of diagnostic evaluation, cardiac magnetic resonance imaging (CMR) is an important adjunctive diagnostic modality with emerging applications for risk-stratification of adverse events in the HCM population. Although not included in current guidelines for HCM management, there is increasing evidence to support the use of CMR for routine prognostic assessment of HCM patients. In this review we discuss the use of CMR techniques, including late gadolinium enhancement, T1 mapping, and quantification of extracellular volume fraction, for the risk stratification of three major adverse events in HCM: sudden cardiac death, ventricular arrhythmias, and congestive heart failure.

Original languageEnglish (US)
Pages (from-to)1147-1156
Number of pages10
JournalInternational Journal of Cardiovascular Imaging
Volume36
Issue number6
DOIs
StatePublished - Jun 1 2020

Keywords

  • ECV fraction
  • Hypertrophic cardiomyopathy
  • Late gadolinium enhancement
  • T1 mapping

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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