Myomir dysregulation and reactive oxygen species in aged human satellite cells

Ester Sara Di Filippo, Rosa Mancinelli, Tiziana Pietrangelo, Rita Maria Laura La Rovere, Mattia Quattrocelli, Maurilio Sampaolesi, Stefania Fulle*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


Satellite cells that reside on the myofibre surface are crucial for the muscle homeostasis and regeneration. Aging goes along with a less effective regeneration of skeletal muscle tissue mainly due to the decreased myogenic capability of satellite cells. This phenomenon impedes proper maintenance and contributes to the age-associated decline in muscle mass, known as sarcopenia. The myogenic potential impairment does not depend on a reduced myogenic cell number, but mainly on their difficulty to complete a differentiation program. The unbalanced production of reactive oxygen species in elderly people could be responsible for skeletal muscle impairments. microRNAs are conserved post-transcriptional regulators implicated in numerous biological processes including adult myogenesis. Here, we measure the ROS level and analyze myomiR (miR-1, miR-133b and miR-206) expression in human myogenic precursors obtained from Vastus lateralis of elderly and young subjects to provide the molecular signature responsible for the differentiation impairment of elderly activated satellite cells.

Original languageEnglish (US)
Pages (from-to)462-470
Number of pages9
JournalBiochemical and Biophysical Research Communications
Issue number2
StatePublished - Apr 29 2016


  • Aging
  • Human satellite cells
  • ROS
  • Sarcopenia
  • myomiRNAs

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology


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