Myoneural necrosis following high-frequency electrical stimulation of the cast-immobilized rabbit hindlimb

Jan Fridén*, Richard L. Lieber, Robert R. Myers, Henry C. Powell, Alan R. Hargens

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


The morphological and physiological effects of 4 weeks of high-frequency electrical stimulation (1 h/day, 5 days/week) on cast-immobilized rabbit hindlimbs were investigated in the tibialis anterior muscle and peroneal nerve. In 2 out of 6 animals, high-frequency stimulation with immobilization caused muscle Fiber death, internalization of muscle Fiber nuclei, connective tissue proliferation, inflammatory response, altered Fiber size distribution and variable staining intensities. The fast-twitch fibers were predominantly affected. Two of six peripheral nerves subjected to immobilization and stimulation showed severe damage. Tetanic forces were significantly reduced in the affected muscles. Therefore, the immobilization and high-frequency stimulation may be detrimental to myoneural structure and function and, thus, this combination of therapies should be applied conservatively.

Original languageEnglish (US)
Pages (from-to)261-273
Number of pages13
JournalStereotactic and Functional Neurosurgery
Issue number4
StatePublished - 1989


  • Functional electrical stimulation
  • Histology
  • Immobilization
  • Morphometry
  • Muscle physiology
  • Myoneural necrosis

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery


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