TY - JOUR
T1 - N-(1-Methyl)cyclopropylbenzylamine
T2 - A novel inactivator of mitochondrial monoamine oxidase
AU - Silverman, Richard B.
AU - Hoffman, Stephen J.
PY - 1981/8/31
Y1 - 1981/8/31
N2 - N-(1-Methyl)cyclopropylbenzylamine was synthesized and shown to inactivate pig liver mitochondrial monoamine oxidase. Inactivation is time-dependent, concentration dependent, protected by the substrate and product of the enzyme, and is not reversed by exhaustive dialysis. Unlike N-cyclopropylbenzylamine, the adduct formed between N-(1-methyl)cyclopropylbenzylamine and monoamine oxidase is stable to treatment with benzylamine. A mechanism for the inactivation is proposed.
AB - N-(1-Methyl)cyclopropylbenzylamine was synthesized and shown to inactivate pig liver mitochondrial monoamine oxidase. Inactivation is time-dependent, concentration dependent, protected by the substrate and product of the enzyme, and is not reversed by exhaustive dialysis. Unlike N-cyclopropylbenzylamine, the adduct formed between N-(1-methyl)cyclopropylbenzylamine and monoamine oxidase is stable to treatment with benzylamine. A mechanism for the inactivation is proposed.
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U2 - 10.1016/0006-291X(81)91602-8
DO - 10.1016/0006-291X(81)91602-8
M3 - Article
C2 - 7306137
AN - SCOPUS:0019805685
VL - 101
SP - 1396
EP - 1401
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
SN - 0006-291X
IS - 4
ER -