N-Acetylprocainamide pharmacokinetics in functionally anephric patients before and after perturbation by hemodialysis

G. Paul Stec; Arthur J. Atkinson; Mary Jane Nevin; Jean Paul Thenot; Tsuen I. Ruo; Thomas P. Gibson; Peter Ivanovich; Francesco del Greco

doi:10.1002/cpt1979265618

N-Acetylprocainamide pharmacokinetics in functionally anephric patients before and after perturbation by hemodialysis

G. Paul Stec, Arthur J. Atkinson^*, Mary Jane Nevin, Jean Paul Thenot, Tsuen I. Ruo, Thomas P. Gibson, Peter Ivanovich, Francesco del Greco

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

NAPA pharmacokinetics were studied in 6 functionally anephric patients. Distribution and nonrenal elimination of this drug were found to be the same as in individuals with normal renal function but renal clearance was reduced, resulting in a mean elimination t^{1 2} of 41.4 hr (6.2 hr in normal subjects). Renal clearance of NAPA correlated well with Cl_Cr. Dialysis removed NAPA from both red blood cells and plasma and increased Cl_T approximately fourfold. Dialysis itself resulted in a 77% reduction in Cl_s that limited the total amount of NAPA removed by this procedure. This reduction in CL, was sustained for tit least 3 hr after dialysis and attenuated rebound in plasma NAPA concentrations.

Original language	English (US)
Pages (from-to)	618-628
Number of pages	11
Journal	Clinical pharmacology and therapeutics
Volume	26
Issue number	5
DOIs	https://doi.org/10.1002/cpt1979265618
State	Published - Nov 1979
Externally published	Yes

ASJC Scopus subject areas

Pharmacology (medical)
Pharmacology

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title = "N-Acetylprocainamide pharmacokinetics in functionally anephric patients before and after perturbation by hemodialysis",

abstract = "NAPA pharmacokinetics were studied in 6 functionally anephric patients. Distribution and nonrenal elimination of this drug were found to be the same as in individuals with normal renal function but renal clearance was reduced, resulting in a mean elimination t 1 2 of 41.4 hr (6.2 hr in normal subjects). Renal clearance of NAPA correlated well with ClCr. Dialysis removed NAPA from both red blood cells and plasma and increased ClT approximately fourfold. Dialysis itself resulted in a 77% reduction in Cls that limited the total amount of NAPA removed by this procedure. This reduction in CL, was sustained for tit least 3 hr after dialysis and attenuated rebound in plasma NAPA concentrations.",

author = "Stec, {G. Paul} and Atkinson, {Arthur J.} and Nevin, {Mary Jane} and Thenot, {Jean Paul} and Ruo, {Tsuen I.} and Gibson, {Thomas P.} and Peter Ivanovich and {del Greco}, Francesco",

year = "1979",

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doi = "10.1002/cpt1979265618",

language = "English (US)",

volume = "26",

pages = "618--628",

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T1 - N-Acetylprocainamide pharmacokinetics in functionally anephric patients before and after perturbation by hemodialysis

AU - Stec, G. Paul

AU - Atkinson, Arthur J.

AU - Nevin, Mary Jane

AU - Thenot, Jean Paul

AU - Ruo, Tsuen I.

AU - Gibson, Thomas P.

AU - Ivanovich, Peter

AU - del Greco, Francesco

PY - 1979/11

Y1 - 1979/11

N2 - NAPA pharmacokinetics were studied in 6 functionally anephric patients. Distribution and nonrenal elimination of this drug were found to be the same as in individuals with normal renal function but renal clearance was reduced, resulting in a mean elimination t 1 2 of 41.4 hr (6.2 hr in normal subjects). Renal clearance of NAPA correlated well with ClCr. Dialysis removed NAPA from both red blood cells and plasma and increased ClT approximately fourfold. Dialysis itself resulted in a 77% reduction in Cls that limited the total amount of NAPA removed by this procedure. This reduction in CL, was sustained for tit least 3 hr after dialysis and attenuated rebound in plasma NAPA concentrations.

AB - NAPA pharmacokinetics were studied in 6 functionally anephric patients. Distribution and nonrenal elimination of this drug were found to be the same as in individuals with normal renal function but renal clearance was reduced, resulting in a mean elimination t 1 2 of 41.4 hr (6.2 hr in normal subjects). Renal clearance of NAPA correlated well with ClCr. Dialysis removed NAPA from both red blood cells and plasma and increased ClT approximately fourfold. Dialysis itself resulted in a 77% reduction in Cls that limited the total amount of NAPA removed by this procedure. This reduction in CL, was sustained for tit least 3 hr after dialysis and attenuated rebound in plasma NAPA concentrations.

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N-Acetylprocainamide pharmacokinetics in functionally anephric patients before and after perturbation by hemodialysis

Abstract

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