N-Acetylprocainamide pharmacokinetics in functionally anephric patients before and after perturbation by hemodialysis

G. Paul Stec, Arthur J. Atkinson*, Mary Jane Nevin, Jean Paul Thenot, Tsuen I. Ruo, Thomas P. Gibson, Peter Ivanovich, Francesco del Greco

*Corresponding author for this work

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

NAPA pharmacokinetics were studied in 6 functionally anephric patients. Distribution and nonrenal elimination of this drug were found to be the same as in individuals with normal renal function but renal clearance was reduced, resulting in a mean elimination t 1 2 of 41.4 hr (6.2 hr in normal subjects). Renal clearance of NAPA correlated well with ClCr. Dialysis removed NAPA from both red blood cells and plasma and increased ClT approximately fourfold. Dialysis itself resulted in a 77% reduction in Cls that limited the total amount of NAPA removed by this procedure. This reduction in CL, was sustained for tit least 3 hr after dialysis and attenuated rebound in plasma NAPA concentrations.

Original languageEnglish (US)
Pages (from-to)618-628
Number of pages11
JournalClinical pharmacology and therapeutics
Volume26
Issue number5
DOIs
StatePublished - Nov 1979

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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    Stec, G. P., Atkinson, A. J., Nevin, M. J., Thenot, J. P., Ruo, T. I., Gibson, T. P., Ivanovich, P., & del Greco, F. (1979). N-Acetylprocainamide pharmacokinetics in functionally anephric patients before and after perturbation by hemodialysis. Clinical pharmacology and therapeutics, 26(5), 618-628. https://doi.org/10.1002/cpt1979265618