NAM-based prediction of point-of-contact toxicity in the lung: A case example with 1,3-dichloropropene

Keyphrases

• Lung 100%
• Contact Point 100%
• Airway 100%
• Contact Toxicity 100%
• 1,3-Dichloropropene (1,3-D) 100%
• Nasal 66%
• In Vivo Testing 33%
• Tissue Response 33%
• Airway Epithelial Cells 33%
• Cytotoxicity 33%
• Alveolar Epithelium 33%
• In Silico 33%
• Ethical Considerations 33%
• Aerosol 33%
• Tissue Concentration 33%
• Exposure Level 33%
• Cell Culture Model 33%
• Airway Epithelium 33%
• Testing Method 33%
• In Vivo Methods 33%
• Acute Exposure 33%
• Regulatory Approval 33%
• In Vitro Experiment 33%
• Epithelial Integrity 33%
• Safety Testing 33%
• Dosimetry Model 33%
• In Vivo Exposure 33%
• Toxicity Assessment 33%
• Bronchiolar 33%
• Epithelial Cell Culture 33%
• Respiratory Tissue 33%
• Lactate Dehydrogenase Release 33%
• Subchronic Study 33%
• Airway Epithelial Cultures 33%
• Cost Consideration 33%
• Exposure Scenario 33%
• Tissue Exposure 33%
• Chemical Safety 33%
• External Exposure 33%
• In Vitro to in Vivo Extrapolation (IVIVE) 33%
• Transepithelial Conductance 33%
• Inhalation Toxicity 33%
• Toxic Vapor 33%

Medicine and Dentistry

• In Vitro 100%
• Lung 100%
• Cell Culture 33%
• Epithelial Cell 16%
• Alveolar Epithelium 16%
• Toxicity Assessment 16%
• In Silico 16%
• Dosimetry 16%
• Lactate Dehydrogenase 16%
• Health Care Cost 16%
• Release Assay 16%
• Tissue Reaction 16%
• Inhalation Toxicity 16%
• Cytotoxicity 16%

Pharmacology, Toxicology and Pharmaceutical Science

• 1,3-Dichloropropene 100%
• Cell Culture 66%
• Dosimetry 33%
• Toxicity Assessment 33%
• Inhalation Toxicity 33%
• Tissue Reaction 33%
• Lactate Dehydrogenase 33%
• Cytotoxicity 33%