Naming Genes for Dystonia: DYT-z or Ditzy?

Niccolo E. Mencacci, H. A. Jinnah

Research output: Contribution to journalArticlepeer-review

Abstract

Dystonias are a clinically and etiologically diverse group of disorders. Numerous genes have now been associated with different dystonia syndromes, and multiple strategies have been proposed for how these genes should be lumped and split into meaningful categories. The traditional approach has been based on the Human Genome Organization's plan for naming genetic loci for all disorders. For dystonia this involves a DYT prefix followed by a number (e.g., DYT1, DYT2, DYT3, etc.). A more recently proposed approach involves assigning multiple prefixes according to the main elements of the phenotype (e.g., DYT, PARK, CHOR, TREM, etc.) followed by the name of the responsible gene. This article describes these nomenclature systems and summarizes some of their limitations. We focus on dystonia as an example, although the concepts may be applied to all movement disorders.

Original languageEnglish (US)
JournalTremor and other hyperkinetic movements (New York, N.Y.)
Volume9
DOIs
StatePublished - Jan 1 2019

Keywords

  • Dystonia
  • gene
  • genetic variant
  • locus
  • mutation
  • nomenclature

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