Nanoconfinement and mass transport in metal-organic frameworks

Conor H. Sharp, Brandon C. Bukowski, Hongyu Li, Eric M. Johnson, Stefan Ilic, Amanda J. Morris, Dilip Gersappe, Randall Q. Snurr, John R. Morris

Research output: Contribution to journalReview articlepeer-review

64 Scopus citations


The ubiquity of metal-organic frameworks in recent scientific literature underscores their highly versatile nature. MOFs have been developed for use in a wide array of applications, including: sensors, catalysis, separations, drug delivery, and electrochemical processes. Often overlooked in the discussion of MOF-based materials is the mass transport of guest molecules within the pores and channels. Given the wide distribution of pore sizes, linker functionalization, and crystal sizes, molecular diffusion within MOFs can be highly dependent on the MOF-guest system. In this review, we discuss the major factors that govern the mass transport of molecules through MOFs at both the intracrystalline and intercrystalline scale; provide an overview of the experimental and computational methods used to measure guest diffusivity within MOFs; and highlight the relevance of mass transfer in the applications of MOFs in electrochemical systems, separations, and heterogeneous catalysis.

Original languageEnglish (US)
Pages (from-to)11530-11558
Number of pages29
JournalChemical Society Reviews
Issue number20
StatePublished - Oct 21 2021

ASJC Scopus subject areas

  • General Chemistry


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