Nanodelivery of traditional Chinese Gingko Biloba extract EGb-761 and bilobalide BN-52021 induces superior neuroprotective effects on pathophysiology of heat stroke

Seaab Sahib, Aruna Sharma*, Dafin F. Muresanu, Zhiqiang Zhang, Cong Li, Z. Ryan Tian, Anca D. Buzoianu, José Vicente Lafuente, Rudy J. Castellani, Ala Nozari, Ranjana Patnaik, Preeti K. Menon, Lars Wiklund, Hari Shanker Sharma

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Military personnel often exposed to high summer heat are vulnerable to heat stroke (HS) resulting in abnormal brain function and mental anomalies. There are reasons to believe that leakage of the blood-brain barrier (BBB) due to hyperthermia and development of brain edema could result in brain pathology. Thus, exploration of suitable therapeutic strategies is needed to induce neuroprotection in HS. Extracts of Gingko Biloba (EGb-761) is traditionally used in a variety of mental disorders in Chinese traditional medicine since ages. In this chapter, effects of TiO2 nanowired EGb-761 and BN-52021 delivery to treat brain pathologies in HS is discussed based on our own investigations. We observed that TiO2 nanowired delivery of EGb-761 or TiO2 BN-52021 is able to attenuate more that 80% reduction in the brain pathology in HS as compared to conventional drug delivery. The functional outcome after HS is also significantly improved by nanowired delivery of EGb-761 and BN-52021. These observations are the first to suggest that nanowired delivery of EGb-761 and BN-52021 has superior therapeutic effects in HS not reported earlier. The clinical significance in relation to the military medicine is discussed.

Original languageEnglish (US)
Title of host publicationNanomedicine and Neuroprotection in Brain Diseases
EditorsHari Shanker Sharma, Aruna Sharma
PublisherElsevier B.V.
Pages249-315
Number of pages67
ISBN (Print)9780323901628
DOIs
StatePublished - Jan 2021
Externally publishedYes

Publication series

NameProgress in Brain Research
Volume265
ISSN (Print)0079-6123
ISSN (Electronic)1875-7855

Keywords

  • Blood-brain barrier
  • Brain edema
  • Brain pathology
  • EGb-761
  • Gingko Biloba
  • Heat stroke
  • Hyperthermia
  • Nanowired delivery
  • Neuroprotection

ASJC Scopus subject areas

  • Neuroscience(all)

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