Nanoparticle-based detection in cerebral spinal fluid of a soluble pathogenic biomarker for Alzheimer's disease

Dimitra G. Georganopoulou, Lei Chang, Jwa Min Nam, C. Shad Thaxton, Elliott J. Mufson, William L. Klein, Chad A. Mirkin*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

713 Scopus citations

Abstract

The recently developed ultrasensitive bio-barcode assay was used to measure the concentration of amyloid-β-derived diffusible ligands (ADDLs), a potential soluble pathogenic Alzheimer's disease (AD) marker, in the cerebrospinal fluid (CSF) of 30 individuals. ADDL concentrations for the subjects diagnosed with AD were consistently higher than the levels in the CSF taken from nondemented age-matched controls. Studies of ADDLs or for any other potential pathogenic AD markers in CSF have not been possible because of their low concentration in CSF (<1 pM). This study is a step toward a diagnostic tool, based on soluble pathogenic markers for the debilitating disease.

Original languageEnglish (US)
Pages (from-to)2273-2276
Number of pages4
JournalProceedings of the National Academy of Sciences of the United States of America
Volume102
Issue number7
DOIs
StatePublished - Feb 15 2005

ASJC Scopus subject areas

  • General

Fingerprint Dive into the research topics of 'Nanoparticle-based detection in cerebral spinal fluid of a soluble pathogenic biomarker for Alzheimer's disease'. Together they form a unique fingerprint.

Cite this