Nanoparticle-based detection in cerebral spinal fluid of a soluble pathogenic biomarker for Alzheimer's disease

Dimitra G. Georganopoulou; Lei Chang; Jwa Min Nam; C. Shad Thaxton; Elliott J. Mufson; William L. Klein; Chad A. Mirkin

doi:10.1073/pnas.0409336102

Nanoparticle-based detection in cerebral spinal fluid of a soluble pathogenic biomarker for Alzheimer's disease

Dimitra G. Georganopoulou, Lei Chang, Jwa Min Nam, C. Shad Thaxton, Elliott J. Mufson, William L. Klein, Chad A. Mirkin^*

^*Corresponding author for this work

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775 Scopus citations

Abstract

The recently developed ultrasensitive bio-barcode assay was used to measure the concentration of amyloid-β-derived diffusible ligands (ADDLs), a potential soluble pathogenic Alzheimer's disease (AD) marker, in the cerebrospinal fluid (CSF) of 30 individuals. ADDL concentrations for the subjects diagnosed with AD were consistently higher than the levels in the CSF taken from nondemented age-matched controls. Studies of ADDLs or for any other potential pathogenic AD markers in CSF have not been possible because of their low concentration in CSF (<1 pM). This study is a step toward a diagnostic tool, based on soluble pathogenic markers for the debilitating disease.

Original language	English (US)
Pages (from-to)	2273-2276
Number of pages	4
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	102
Issue number	7
DOIs	https://doi.org/10.1073/pnas.0409336102
State	Published - Feb 15 2005

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title = "Nanoparticle-based detection in cerebral spinal fluid of a soluble pathogenic biomarker for Alzheimer's disease",

abstract = "The recently developed ultrasensitive bio-barcode assay was used to measure the concentration of amyloid-β-derived diffusible ligands (ADDLs), a potential soluble pathogenic Alzheimer's disease (AD) marker, in the cerebrospinal fluid (CSF) of 30 individuals. ADDL concentrations for the subjects diagnosed with AD were consistently higher than the levels in the CSF taken from nondemented age-matched controls. Studies of ADDLs or for any other potential pathogenic AD markers in CSF have not been possible because of their low concentration in CSF (<1 pM). This study is a step toward a diagnostic tool, based on soluble pathogenic markers for the debilitating disease.",

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Nanoparticle-based detection in cerebral spinal fluid of a soluble pathogenic biomarker for Alzheimer's disease. / Georganopoulou, Dimitra G.; Chang, Lei; Nam, Jwa Min et al.
In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, No. 7, 15.02.2005, p. 2273-2276.

Research output: Contribution to journal › Article › peer-review

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AU - Nam, Jwa Min

AU - Thaxton, C. Shad

AU - Mufson, Elliott J.

AU - Klein, William L.

AU - Mirkin, Chad A.

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AB - The recently developed ultrasensitive bio-barcode assay was used to measure the concentration of amyloid-β-derived diffusible ligands (ADDLs), a potential soluble pathogenic Alzheimer's disease (AD) marker, in the cerebrospinal fluid (CSF) of 30 individuals. ADDL concentrations for the subjects diagnosed with AD were consistently higher than the levels in the CSF taken from nondemented age-matched controls. Studies of ADDLs or for any other potential pathogenic AD markers in CSF have not been possible because of their low concentration in CSF (<1 pM). This study is a step toward a diagnostic tool, based on soluble pathogenic markers for the debilitating disease.

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Nanoparticle-based detection in cerebral spinal fluid of a soluble pathogenic biomarker for Alzheimer's disease

Abstract

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