Nanoparticle-programmed self-destructive neural stem cells for glioblastoma targeting and therapy

Yu Cheng; Ramin Morshed; Shih Hsun Cheng; Alex Tobias; Brenda Auffinger; Derek A. Wainwright; Lingjiao Zhang; Catherine Yunis; Yu Han; Chin Tu Chen; Leu Wei Lo; Karen S. Aboody; Atique U. Ahmed; Maciej S. Lesniak

doi:10.1002/smll.201301111

Nanoparticle-programmed self-destructive neural stem cells for glioblastoma targeting and therapy

Yu Cheng, Ramin Morshed, Shih Hsun Cheng, Alex Tobias, Brenda Auffinger, Derek A. Wainwright, Lingjiao Zhang, Catherine Yunis, Yu Han, Chin Tu Chen^*, Leu Wei Lo, Karen S. Aboody, Atique U. Ahmed, Maciej S. Lesniak

^*Corresponding author for this work

Neurological Surgery

Research output: Contribution to journal › Article › peer-review

50 Scopus citations

Abstract

A 3-step glioblastoma-tropic delivery and therapy method using nanoparticle programmed self-destructive neural stem cells (NSCs) is demonstrated in vivo: 1) FDA-approved NSCs for clinical trials are loaded with pH-sensitive MSN-Dox; 2) the nanoparticle conjugates provide a delayed drug-releasing mechanism and allow for NSC migration towards a distant tumor site; 3) NSCs eventually undergo cell death and release impregnated MSN-Dox, which subsequently induces toxicity towards surrounding glioma cells.

Original language	English (US)
Pages (from-to)	4123-4129
Number of pages	7
Journal	Small
Volume	9
Issue number	24
DOIs	https://doi.org/10.1002/smll.201301111
State	Published - Dec 20 2013

Keywords

doxorubicin
drug delivery
glioblastoma
glioma
mesoporous silica nanoparticles
neural stem cells
targeted delivery

ASJC Scopus subject areas

Biotechnology
Biomaterials
Chemistry(all)
Materials Science(all)

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Cheng, Yu ; Morshed, Ramin ; Cheng, Shih Hsun ; Tobias, Alex ; Auffinger, Brenda ; Wainwright, Derek A. ; Zhang, Lingjiao ; Yunis, Catherine ; Han, Yu ; Chen, Chin Tu ; Lo, Leu Wei ; Aboody, Karen S. ; Ahmed, Atique U. ; Lesniak, Maciej S. / Nanoparticle-programmed self-destructive neural stem cells for glioblastoma targeting and therapy. In: Small. 2013 ; Vol. 9, No. 24. pp. 4123-4129.

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title = "Nanoparticle-programmed self-destructive neural stem cells for glioblastoma targeting and therapy",

abstract = "A 3-step glioblastoma-tropic delivery and therapy method using nanoparticle programmed self-destructive neural stem cells (NSCs) is demonstrated in vivo: 1) FDA-approved NSCs for clinical trials are loaded with pH-sensitive MSN-Dox; 2) the nanoparticle conjugates provide a delayed drug-releasing mechanism and allow for NSC migration towards a distant tumor site; 3) NSCs eventually undergo cell death and release impregnated MSN-Dox, which subsequently induces toxicity towards surrounding glioma cells.",

keywords = "doxorubicin, drug delivery, glioblastoma, glioma, mesoporous silica nanoparticles, neural stem cells, targeted delivery",

author = "Yu Cheng and Ramin Morshed and Cheng, {Shih Hsun} and Alex Tobias and Brenda Auffinger and Wainwright, {Derek A.} and Lingjiao Zhang and Catherine Yunis and Yu Han and Chen, {Chin Tu} and Lo, {Leu Wei} and Aboody, {Karen S.} and Ahmed, {Atique U.} and Lesniak, {Maciej S.}",

year = "2013",

month = dec,

day = "20",

doi = "10.1002/smll.201301111",

language = "English (US)",

volume = "9",

pages = "4123--4129",

journal = "Small",

issn = "1613-6810",

publisher = "Wiley-VCH Verlag",

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Nanoparticle-programmed self-destructive neural stem cells for glioblastoma targeting and therapy. / Cheng, Yu; Morshed, Ramin; Cheng, Shih Hsun; Tobias, Alex; Auffinger, Brenda; Wainwright, Derek A.; Zhang, Lingjiao; Yunis, Catherine; Han, Yu; Chen, Chin Tu; Lo, Leu Wei; Aboody, Karen S.; Ahmed, Atique U.; Lesniak, Maciej S.

In: Small, Vol. 9, No. 24, 20.12.2013, p. 4123-4129.

Research output: Contribution to journal › Article › peer-review

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T1 - Nanoparticle-programmed self-destructive neural stem cells for glioblastoma targeting and therapy

AU - Cheng, Yu

AU - Morshed, Ramin

AU - Cheng, Shih Hsun

AU - Tobias, Alex

AU - Auffinger, Brenda

AU - Wainwright, Derek A.

AU - Zhang, Lingjiao

AU - Yunis, Catherine

AU - Han, Yu

AU - Chen, Chin Tu

AU - Lo, Leu Wei

AU - Aboody, Karen S.

AU - Ahmed, Atique U.

AU - Lesniak, Maciej S.

PY - 2013/12/20

Y1 - 2013/12/20

N2 - A 3-step glioblastoma-tropic delivery and therapy method using nanoparticle programmed self-destructive neural stem cells (NSCs) is demonstrated in vivo: 1) FDA-approved NSCs for clinical trials are loaded with pH-sensitive MSN-Dox; 2) the nanoparticle conjugates provide a delayed drug-releasing mechanism and allow for NSC migration towards a distant tumor site; 3) NSCs eventually undergo cell death and release impregnated MSN-Dox, which subsequently induces toxicity towards surrounding glioma cells.

AB - A 3-step glioblastoma-tropic delivery and therapy method using nanoparticle programmed self-destructive neural stem cells (NSCs) is demonstrated in vivo: 1) FDA-approved NSCs for clinical trials are loaded with pH-sensitive MSN-Dox; 2) the nanoparticle conjugates provide a delayed drug-releasing mechanism and allow for NSC migration towards a distant tumor site; 3) NSCs eventually undergo cell death and release impregnated MSN-Dox, which subsequently induces toxicity towards surrounding glioma cells.

KW - doxorubicin

KW - drug delivery

KW - glioblastoma

KW - glioma

KW - mesoporous silica nanoparticles

KW - neural stem cells

KW - targeted delivery

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Nanoparticle-programmed self-destructive neural stem cells for glioblastoma targeting and therapy

Abstract

Keywords

ASJC Scopus subject areas

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