Nanoporous biodegradable elastomers

Ryan A. Hoshi, Saloni Behl, Guillermo A. Ameer

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

Nanoporous poly(1,8-octanediol-co-citrate) (POC) was engineered to have a high degree of interconnectivity and porosity, and a large internal surface area. POC pre-polymer was synthesized and equimolar amounts of citric acid and 1,8-octanediol were added to a 250mL three-neck round-bottom flask fitted with an inlet and outlet adapter. The mixture was melted under a flow of nitrogen gas by magnetic stirring at 160-165°C in a silicon oil bath and then the temperature of the system was lowered to 140°C to create a pre-polymer. The purification process was repeated twice and the collected pre-polymer was freeze-dried. The foreign body response was evaluated through subcutaneous implantation in Spraque-Dawley rats for POC-0 and PEGDM-leached POC-75 samples to access the feasibility of using nanoporous POC for drug-delivery applications. It was observed that the biocompatibility data and versatility of the drug encapsulation method make nanoporous POC a promising platform for several soft tissue engineering applications.

Original languageEnglish (US)
Pages (from-to)188-192
Number of pages5
JournalAdvanced Materials
Volume21
Issue number2
DOIs
StatePublished - Jan 12 2009

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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