Nanoporous poly(1,8-octanediol-co-citrate) (POC) was engineered to have a high degree of interconnectivity and porosity, and a large internal surface area. POC pre-polymer was synthesized and equimolar amounts of citric acid and 1,8-octanediol were added to a 250mL three-neck round-bottom flask fitted with an inlet and outlet adapter. The mixture was melted under a flow of nitrogen gas by magnetic stirring at 160-165°C in a silicon oil bath and then the temperature of the system was lowered to 140°C to create a pre-polymer. The purification process was repeated twice and the collected pre-polymer was freeze-dried. The foreign body response was evaluated through subcutaneous implantation in Spraque-Dawley rats for POC-0 and PEGDM-leached POC-75 samples to access the feasibility of using nanoporous POC for drug-delivery applications. It was observed that the biocompatibility data and versatility of the drug encapsulation method make nanoporous POC a promising platform for several soft tissue engineering applications.
|Original language||English (US)|
|Number of pages||5|
|State||Published - Jan 12 2009|
ASJC Scopus subject areas
- Materials Science(all)
- Mechanics of Materials
- Mechanical Engineering