Nanoporous biodegradable elastomers

Ryan A. Hoshi; Saloni Behl; Guillermo A. Ameer

doi:10.1002/adma.200801132

Nanoporous biodegradable elastomers

Ryan A. Hoshi, Saloni Behl, Guillermo A. Ameer

Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

Nanoporous poly(1,8-octanediol-co-citrate) (POC) was engineered to have a high degree of interconnectivity and porosity, and a large internal surface area. POC pre-polymer was synthesized and equimolar amounts of citric acid and 1,8-octanediol were added to a 250mL three-neck round-bottom flask fitted with an inlet and outlet adapter. The mixture was melted under a flow of nitrogen gas by magnetic stirring at 160-165°C in a silicon oil bath and then the temperature of the system was lowered to 140°C to create a pre-polymer. The purification process was repeated twice and the collected pre-polymer was freeze-dried. The foreign body response was evaluated through subcutaneous implantation in Spraque-Dawley rats for POC-0 and PEGDM-leached POC-75 samples to access the feasibility of using nanoporous POC for drug-delivery applications. It was observed that the biocompatibility data and versatility of the drug encapsulation method make nanoporous POC a promising platform for several soft tissue engineering applications.

Original language	English (US)
Pages (from-to)	188-192
Number of pages	5
Journal	Advanced Materials
Volume	21
Issue number	2
DOIs	https://doi.org/10.1002/adma.200801132
State	Published - Jan 12 2009

ASJC Scopus subject areas

Materials Science(all)
Mechanics of Materials
Mechanical Engineering

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title = "Nanoporous biodegradable elastomers",

abstract = "Nanoporous poly(1,8-octanediol-co-citrate) (POC) was engineered to have a high degree of interconnectivity and porosity, and a large internal surface area. POC pre-polymer was synthesized and equimolar amounts of citric acid and 1,8-octanediol were added to a 250mL three-neck round-bottom flask fitted with an inlet and outlet adapter. The mixture was melted under a flow of nitrogen gas by magnetic stirring at 160-165°C in a silicon oil bath and then the temperature of the system was lowered to 140°C to create a pre-polymer. The purification process was repeated twice and the collected pre-polymer was freeze-dried. The foreign body response was evaluated through subcutaneous implantation in Spraque-Dawley rats for POC-0 and PEGDM-leached POC-75 samples to access the feasibility of using nanoporous POC for drug-delivery applications. It was observed that the biocompatibility data and versatility of the drug encapsulation method make nanoporous POC a promising platform for several soft tissue engineering applications.",

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AU - Behl, Saloni

AU - Ameer, Guillermo A.

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N2 - Nanoporous poly(1,8-octanediol-co-citrate) (POC) was engineered to have a high degree of interconnectivity and porosity, and a large internal surface area. POC pre-polymer was synthesized and equimolar amounts of citric acid and 1,8-octanediol were added to a 250mL three-neck round-bottom flask fitted with an inlet and outlet adapter. The mixture was melted under a flow of nitrogen gas by magnetic stirring at 160-165°C in a silicon oil bath and then the temperature of the system was lowered to 140°C to create a pre-polymer. The purification process was repeated twice and the collected pre-polymer was freeze-dried. The foreign body response was evaluated through subcutaneous implantation in Spraque-Dawley rats for POC-0 and PEGDM-leached POC-75 samples to access the feasibility of using nanoporous POC for drug-delivery applications. It was observed that the biocompatibility data and versatility of the drug encapsulation method make nanoporous POC a promising platform for several soft tissue engineering applications.

AB - Nanoporous poly(1,8-octanediol-co-citrate) (POC) was engineered to have a high degree of interconnectivity and porosity, and a large internal surface area. POC pre-polymer was synthesized and equimolar amounts of citric acid and 1,8-octanediol were added to a 250mL three-neck round-bottom flask fitted with an inlet and outlet adapter. The mixture was melted under a flow of nitrogen gas by magnetic stirring at 160-165°C in a silicon oil bath and then the temperature of the system was lowered to 140°C to create a pre-polymer. The purification process was repeated twice and the collected pre-polymer was freeze-dried. The foreign body response was evaluated through subcutaneous implantation in Spraque-Dawley rats for POC-0 and PEGDM-leached POC-75 samples to access the feasibility of using nanoporous POC for drug-delivery applications. It was observed that the biocompatibility data and versatility of the drug encapsulation method make nanoporous POC a promising platform for several soft tissue engineering applications.

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Nanoporous biodegradable elastomers

Abstract

ASJC Scopus subject areas

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