Nanoscale graphene oxide (nGO) as artificial receptors: Implications for biomolecular interactions and sensing

Stanley S. Chou*, Mrinmoy De, Jiayan Luo, Vincent M. Rotello, Jiaxing Huang, Vinayak P. Dravid

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

182 Scopus citations


The role of conventional graphene-oxide in biosensing has been limited to that of a quenching substrate or signal transducer due to size inconsistencies and poor supramolecular response. We overcame these issues by using nanoscale GOs (nGO) as artificial receptors. Unlike conventional GO, nGOs are sheets with near uniform lateral dimension of 20 nm. Due to its nanoscale architecture, its supramolecular response was enhanced, with demonstrated improvements in biomacromolecular affinities. This rendered their surface capable of detecting unknown proteins with cognizance not seen with conventional GOs. Different proteins at 100 and 10 nM concentrations revealed consistent patterns that are quantitatively differentiable by linear discriminant analysis. Identification of 48 unknowns in both concentrations demonstrated a >95% success rate. The 10 nM detection represents a 10-fold improvement over analogous arrays. This demonstrates for the first time that the supramolecular chemistry of GO is highly size dependent and opens the possibility of improvement upon existing GO hybrid materials.

Original languageEnglish (US)
Pages (from-to)16725-16733
Number of pages9
JournalJournal of the American Chemical Society
Issue number40
StatePublished - Oct 10 2012

ASJC Scopus subject areas

  • General Chemistry
  • Biochemistry
  • Catalysis
  • Colloid and Surface Chemistry


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