Nanoscale plasmonics begins to unravel Alzheimer's disease

Amanda J. Haes*, W. Paige Hall, Richard P. Van Duyne

*Corresponding author for this work

Research output: Contribution to specialist publicationArticle

11 Scopus citations


The technique to detect a variety of ligands, including a biomarker for Alzheimer's disease, by using an optical sensor based on localized surface-plasmon-resonance spectroscopy was described. It was observed that the surface-plasmon-resonance sensors detect the local refractive-index changes that occur when a target analyte binds to the metal film. The calculations show that the sensing range is determined by the falloff of the average electric field around the nanoparticle. It was found that the silver nanoparticles with in-plane widths of about 90 nm and heights of 25 nm produced electromagnetic fields that extend to about 35 nm away from the nanoparticle surface.

Original languageEnglish (US)
Number of pages5
Specialist publicationLaser Focus World
StatePublished - Jun 1 2005

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Condensed Matter Physics
  • Marketing
  • Electrical and Electronic Engineering


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