Nanosizing a Metal-Organic Framework Enzyme Carrier for Accelerating Nerve Agent Hydrolysis

Peng Li, Su Young Moon, Mark A. Guelta, Lu Lin, Diego A. Gómez-Gualdrón, Randall Q. Snurr, Steven P. Harvey, Joseph T. Hupp, Omar K. Farha*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

155 Scopus citations


We report the synthesis and characterization of a water-stable zirconium metal-organic framework (MOF), NU-1003, featuring the largest mesoporous aperture known for a zirconium MOF. This material has been used to immobilize the nerve agent hydrolyzing enzyme, organophosphorus acid anhydrolase (OPAA). The catalytic efficiency of immobilized OPAA in nanosized NU-1003 is significantly increased compared to that of OPAA immobilized in microsized NU-1003 and even exceeds that of the free OPAA enzyme. This paper highlights a method for rapid and highly efficient hydrolysis of nerve agents using nanosized enzyme carriers.

Original languageEnglish (US)
Pages (from-to)9174-9182
Number of pages9
JournalACS nano
Issue number10
StatePublished - Oct 25 2016


  • enzyme immobilization
  • metal-organic framework
  • nanocarrier
  • nerve agent catalysis

ASJC Scopus subject areas

  • Materials Science(all)
  • Engineering(all)
  • Physics and Astronomy(all)


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