Nanostructured biomolecular detectors: Pushing performance at the nanoscale

Kristin B. Cederquist, Shana O. Kelley*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

33 Scopus citations


Nanomaterial-based biosensing strategies offer a number of advantages over traditional molecular diagnostic and cellular analysis techniques, including signal amplification, improved sensitivity and speed, and versatile sensing schemes that can be tailored to a desired target. In this article, we highlight a variety of nanomaterial-based sensors, and discuss the advantages of different nanomaterials compositions and probes of different biomolecular classes. Recent advances in the development of optical, electrical, or electrochemical transduction mechanisms are covered, with special regard to breakthroughs in sensitivity. The works reviewed herein emphasize the improvements that nanomaterials offer in the realm of diagnostic assays and make a solid case for further advancement with automation and multiplexing.

Original languageEnglish (US)
Pages (from-to)415-421
Number of pages7
JournalCurrent Opinion in Chemical Biology
Issue number3-4
StatePublished - Aug 2012
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry


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