TY - JOUR
T1 - Nanostructured biomolecular detectors
T2 - Pushing performance at the nanoscale
AU - Cederquist, Kristin B.
AU - Kelley, Shana O.
N1 - Funding Information:
We acknowledge the support of the Canadian Institute for Health Research , the Natural Sciences and Engineering Research Council , the Ontario Research Fund , and the US Department of Defense (DARPA) for their generous support of our work in this area.
PY - 2012/8
Y1 - 2012/8
N2 - Nanomaterial-based biosensing strategies offer a number of advantages over traditional molecular diagnostic and cellular analysis techniques, including signal amplification, improved sensitivity and speed, and versatile sensing schemes that can be tailored to a desired target. In this article, we highlight a variety of nanomaterial-based sensors, and discuss the advantages of different nanomaterials compositions and probes of different biomolecular classes. Recent advances in the development of optical, electrical, or electrochemical transduction mechanisms are covered, with special regard to breakthroughs in sensitivity. The works reviewed herein emphasize the improvements that nanomaterials offer in the realm of diagnostic assays and make a solid case for further advancement with automation and multiplexing.
AB - Nanomaterial-based biosensing strategies offer a number of advantages over traditional molecular diagnostic and cellular analysis techniques, including signal amplification, improved sensitivity and speed, and versatile sensing schemes that can be tailored to a desired target. In this article, we highlight a variety of nanomaterial-based sensors, and discuss the advantages of different nanomaterials compositions and probes of different biomolecular classes. Recent advances in the development of optical, electrical, or electrochemical transduction mechanisms are covered, with special regard to breakthroughs in sensitivity. The works reviewed herein emphasize the improvements that nanomaterials offer in the realm of diagnostic assays and make a solid case for further advancement with automation and multiplexing.
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U2 - 10.1016/j.cbpa.2012.04.011
DO - 10.1016/j.cbpa.2012.04.011
M3 - Review article
C2 - 22771285
AN - SCOPUS:84865305419
SN - 1367-5931
VL - 16
SP - 415
EP - 421
JO - Current Opinion in Chemical Biology
JF - Current Opinion in Chemical Biology
IS - 3-4
ER -