Nanostructured microelectrodes for electrochemical sensing in digital microfluidic devices

Darius G. Rackus*, Michael D.M. Dryden, Alex Zaragoza, Julian Lamanna, Brian Lam, Shana O. Kelley, Aaron R. Wheeler

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Nanostructured microelectrodes (NMEs) are three-dimensional electrodes with superb sensitivity. Here we report the integration of NMEs with digital microfluidics (DMF), for eventual application to diagnostics outside of the laboratory. The new system was observed to outperform similar planar sensing electrodes also integrated with DMF. A rubella virus (RV) IgG immunoassay was developed to evaluate the diagnostic potential for the new system. The limit of detection of the assay (0.80 IU mL-1) was >10x below the World Health Organization defined cut-off for rubella immunity.

Original languageEnglish (US)
Title of host publicationMicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherChemical and Biological Microsystems Society
Pages88-90
Number of pages3
ISBN (Electronic)9780979806483
StatePublished - 2015
Event19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015 - Gyeongju, Korea, Republic of
Duration: Oct 25 2015Oct 29 2015

Publication series

NameMicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences

Conference

Conference19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015
Country/TerritoryKorea, Republic of
CityGyeongju
Period10/25/1510/29/15

Funding

We thank the Canadian Institutes for Health Research (CIHR), the National Science and Engineering Research Council (NSERC), and Abbott Diagnostics for support. We thank Drs. Mohtashim Shamsi and Alphonsus Ng (Univ. Toronto) for advice. D.G.R acknowledges support from the Ontario Graduate Scholarship. A.R.W. thanks the Canada Research Chair (CRC) Program for a CRC.

ASJC Scopus subject areas

  • Control and Systems Engineering

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