Abstract
Nanostructured microelectrodes (NMEs) are three-dimensional electrodes with superb sensitivity. Here we report the integration of NMEs with digital microfluidics (DMF), for eventual application to diagnostics outside of the laboratory. The new system was observed to outperform similar planar sensing electrodes also integrated with DMF. A rubella virus (RV) IgG immunoassay was developed to evaluate the diagnostic potential for the new system. The limit of detection of the assay (0.80 IU mL-1) was >10x below the World Health Organization defined cut-off for rubella immunity.
| Original language | English (US) |
|---|---|
| Title of host publication | MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences |
| Publisher | Chemical and Biological Microsystems Society |
| Pages | 88-90 |
| Number of pages | 3 |
| ISBN (Electronic) | 9780979806483 |
| State | Published - 2015 |
| Event | 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015 - Gyeongju, Korea, Republic of Duration: Oct 25 2015 → Oct 29 2015 |
Publication series
| Name | MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences |
|---|
Conference
| Conference | 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015 |
|---|---|
| Country/Territory | Korea, Republic of |
| City | Gyeongju |
| Period | 10/25/15 → 10/29/15 |
Funding
We thank the Canadian Institutes for Health Research (CIHR), the National Science and Engineering Research Council (NSERC), and Abbott Diagnostics for support. We thank Drs. Mohtashim Shamsi and Alphonsus Ng (Univ. Toronto) for advice. D.G.R acknowledges support from the Ontario Graduate Scholarship. A.R.W. thanks the Canada Research Chair (CRC) Program for a CRC.
ASJC Scopus subject areas
- Control and Systems Engineering