TY - GEN
T1 - Nanostructured microelectrodes for electrochemical sensing in digital microfluidic devices
AU - Rackus, Darius G.
AU - Dryden, Michael D.M.
AU - Zaragoza, Alex
AU - Lamanna, Julian
AU - Lam, Brian
AU - Kelley, Shana O.
AU - Wheeler, Aaron R.
N1 - Funding Information:
We thank the Canadian Institutes for Health Research (CIHR), the National Science and Engineering Research Council (NSERC), and Abbott Diagnostics for support. We thank Drs. Mohtashim Shamsi and Alphonsus Ng (Univ. Toronto) for advice. D.G.R acknowledges support from the Ontario Graduate Scholarship. A.R.W. thanks the Canada Research Chair (CRC) Program for a CRC.
Publisher Copyright:
© 15CBMS-0001.
PY - 2015
Y1 - 2015
N2 - Nanostructured microelectrodes (NMEs) are three-dimensional electrodes with superb sensitivity. Here we report the integration of NMEs with digital microfluidics (DMF), for eventual application to diagnostics outside of the laboratory. The new system was observed to outperform similar planar sensing electrodes also integrated with DMF. A rubella virus (RV) IgG immunoassay was developed to evaluate the diagnostic potential for the new system. The limit of detection of the assay (0.80 IU mL-1) was >10x below the World Health Organization defined cut-off for rubella immunity.
AB - Nanostructured microelectrodes (NMEs) are three-dimensional electrodes with superb sensitivity. Here we report the integration of NMEs with digital microfluidics (DMF), for eventual application to diagnostics outside of the laboratory. The new system was observed to outperform similar planar sensing electrodes also integrated with DMF. A rubella virus (RV) IgG immunoassay was developed to evaluate the diagnostic potential for the new system. The limit of detection of the assay (0.80 IU mL-1) was >10x below the World Health Organization defined cut-off for rubella immunity.
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M3 - Conference contribution
AN - SCOPUS:84983335609
T3 - MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences
SP - 88
EP - 90
BT - MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PB - Chemical and Biological Microsystems Society
T2 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015
Y2 - 25 October 2015 through 29 October 2015
ER -