Nanostructures in biodiagnostics

Nathaniel L. Rosi, Chad A. Mirkin*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

4041 Scopus citations

Abstract

The promise of nanostructure-based biodiagnostic assays is assessed with respect to how they compare with the PCR/molecular fluorophore approach for DNA or ELISAs for proteins. Dendrimers are used as a means to increase the number of labels associated with each target binding event. Using a dendrimer probe containing 250 fluorophores, the fluorescent assay sensitivity increases by a factor of ∼16. However, the dendrimer introduces an additional level of synthetic complexity to the assay. Electrochemical assays based upon molecular probes are attractive because of their low cost and simplicity.

Original languageEnglish (US)
Pages (from-to)1547-1562
Number of pages16
JournalChemical Reviews
Volume105
Issue number4
DOIs
StatePublished - Apr 1 2005

ASJC Scopus subject areas

  • Chemistry(all)

Fingerprint Dive into the research topics of 'Nanostructures in biodiagnostics'. Together they form a unique fingerprint.

Cite this