Nanostructures in biodiagnostics

Nathaniel L. Rosi, Chad A. Mirkin*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

4280 Scopus citations


The promise of nanostructure-based biodiagnostic assays is assessed with respect to how they compare with the PCR/molecular fluorophore approach for DNA or ELISAs for proteins. Dendrimers are used as a means to increase the number of labels associated with each target binding event. Using a dendrimer probe containing 250 fluorophores, the fluorescent assay sensitivity increases by a factor of ∼16. However, the dendrimer introduces an additional level of synthetic complexity to the assay. Electrochemical assays based upon molecular probes are attractive because of their low cost and simplicity.

Original languageEnglish (US)
Pages (from-to)1547-1562
Number of pages16
JournalChemical Reviews
Issue number4
StatePublished - Apr 2005

ASJC Scopus subject areas

  • Chemistry(all)


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