Nanotechnology for synthetic high-density lipoproteins

Andrea J. Luthi, Pinal C. Patel, Caroline H. Ko, R. Kannan Mutharasan, Chad A. Mirkin*, C. Shad Thaxton

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review

20 Scopus citations

Abstract

Atherosclerosis is the disease mechanism responsible for coronary heart disease (CHD), the leading cause of death worldwide. One strategy to combat atherosclerosis is to increase the amount of circulating high-density lipoproteins (HDL), which transport cholesterol from peripheral tissues to the liver for excretion. The process, known as reverse cholesterol transport, is thought to be one of the main reasons for the significant inverse correlation observed between HDL blood levels and the development of CHD. This article highlights the most common strategies for treating atherosclerosis using HDL. We further detail potential treatment opportunities that utilize nanotechnology to increase the amount of HDL in circulation. The synthesis of biomimetic HDL nanostructures that replicate the chemical and physical properties of natural HDL provides novel materials for investigating the structure-function relationships of HDL and for potential new therapeutics to combat CHD.

Original languageEnglish (US)
Pages (from-to)553-560
Number of pages8
JournalTrends in Molecular Medicine
Volume16
Issue number12
DOIs
StatePublished - Dec 1 2010

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

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