Nanotherapeutics in transplantation: How do we get to clinical implementation?

Leah Plumblee; Carl Atkinson; Dinesh Jaishankar; Evan Scott; Gregory T. Tietjen; Satish N. Nadig

doi:10.1111/ajt.17012

Nanotherapeutics in transplantation: How do we get to clinical implementation?

Leah Plumblee, Carl Atkinson, Dinesh Jaishankar, Evan Scott, Gregory T. Tietjen, Satish N. Nadig^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

Abstract

Patients undergoing organ transplantation transition from one life-altering issue (organ dysfunction) to a lifelong commitment—immunosuppression. Regimens of immunosuppressive agents (ISAs) come with significant side effects and comorbidities. Recently, the use of nanoparticles (NPs) as a solution to the problems associated with the long-term and systemic use of ISAs in transplantation has emerged. This minireview describes the role of NPs in organ transplantation and discusses obstacles to clinical implementation and pathways to clinical translation.

Original language	English (US)
Pages (from-to)	1293-1298
Number of pages	6
Journal	American Journal of Transplantation
Volume	22
Issue number	5
DOIs	https://doi.org/10.1111/ajt.17012
State	Published - May 2022
Externally published	Yes

Keywords

basic (laboratory) research/science
bioengineering
graft survival
immunosuppressant
immunosuppression/immune modulation
organ perfusion and preservation
organ transplantation in general
solid organ transplantation
translational research/science

ASJC Scopus subject areas

Immunology and Allergy
Transplantation
Pharmacology (medical)

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10.1111/ajt.17012

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title = "Nanotherapeutics in transplantation: How do we get to clinical implementation?",

abstract = "Patients undergoing organ transplantation transition from one life-altering issue (organ dysfunction) to a lifelong commitment—immunosuppression. Regimens of immunosuppressive agents (ISAs) come with significant side effects and comorbidities. Recently, the use of nanoparticles (NPs) as a solution to the problems associated with the long-term and systemic use of ISAs in transplantation has emerged. This minireview describes the role of NPs in organ transplantation and discusses obstacles to clinical implementation and pathways to clinical translation.",

keywords = "basic (laboratory) research/science, bioengineering, graft survival, immunosuppressant, immunosuppression/immune modulation, organ perfusion and preservation, organ transplantation in general, solid organ transplantation, translational research/science",

author = "Leah Plumblee and Carl Atkinson and Dinesh Jaishankar and Evan Scott and Tietjen, {Gregory T.} and Nadig, {Satish N.}",

note = "Funding Information: Research reported in this publication was supported by the National Institute of Health (SNN: NIBIB K08EB019495, CA: NHLBI R01HL140470, LP: NIH T32 HL007260, GT: NIDDK R01DK124420). Publisher Copyright: {\textcopyright} 2022 The Authors. American Journal of Transplantation published by Wiley Periodicals LLC on behalf of The American Society of Transplantation and the American Society of Transplant Surgeons.",

year = "2022",

month = may,

doi = "10.1111/ajt.17012",

language = "English (US)",

volume = "22",

pages = "1293--1298",

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AU - Plumblee, Leah

AU - Atkinson, Carl

AU - Jaishankar, Dinesh

AU - Scott, Evan

AU - Tietjen, Gregory T.

AU - Nadig, Satish N.

N1 - Funding Information: Research reported in this publication was supported by the National Institute of Health (SNN: NIBIB K08EB019495, CA: NHLBI R01HL140470, LP: NIH T32 HL007260, GT: NIDDK R01DK124420). Publisher Copyright: © 2022 The Authors. American Journal of Transplantation published by Wiley Periodicals LLC on behalf of The American Society of Transplantation and the American Society of Transplant Surgeons.

PY - 2022/5

Y1 - 2022/5

N2 - Patients undergoing organ transplantation transition from one life-altering issue (organ dysfunction) to a lifelong commitment—immunosuppression. Regimens of immunosuppressive agents (ISAs) come with significant side effects and comorbidities. Recently, the use of nanoparticles (NPs) as a solution to the problems associated with the long-term and systemic use of ISAs in transplantation has emerged. This minireview describes the role of NPs in organ transplantation and discusses obstacles to clinical implementation and pathways to clinical translation.

AB - Patients undergoing organ transplantation transition from one life-altering issue (organ dysfunction) to a lifelong commitment—immunosuppression. Regimens of immunosuppressive agents (ISAs) come with significant side effects and comorbidities. Recently, the use of nanoparticles (NPs) as a solution to the problems associated with the long-term and systemic use of ISAs in transplantation has emerged. This minireview describes the role of NPs in organ transplantation and discusses obstacles to clinical implementation and pathways to clinical translation.

KW - basic (laboratory) research/science

KW - bioengineering

KW - graft survival

KW - immunosuppressant

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KW - organ perfusion and preservation

KW - organ transplantation in general

KW - solid organ transplantation

KW - translational research/science

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ER -

Nanotherapeutics in transplantation: How do we get to clinical implementation?

Abstract

Keywords

ASJC Scopus subject areas

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