Nanowired delivery of cerebrolysin with neprilysin and p-Tau antibodies induces superior neuroprotection in Alzheimer's disease

Hari Shanker Sharma; Dafin F. Muresanu; Rudy J. Castellani; Ala Nozari; José Vicente Lafuente; Z. Ryan Tian; Asya Ozkizilcik; Igor Manzhulo; Herbert Mössler; Aruna Sharma

doi:10.1016/bs.pbr.2019.03.009

Nanowired delivery of cerebrolysin with neprilysin and p-Tau antibodies induces superior neuroprotection in Alzheimer's disease

Hari Shanker Sharma^*, Dafin F. Muresanu, Rudy J. Castellani, Ala Nozari, José Vicente Lafuente, Z. Ryan Tian, Asya Ozkizilcik, Igor Manzhulo, Herbert Mössler, Aruna Sharma

^*Corresponding author for this work

Pathology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

30 Scopus citations

Abstract

Alzheimer's disease (AD) is estimated to be afflicting over 55 millions of individual worldwide in 2018–19 for which no suitable clinical therapeutic measures have been developed so far. Thus, there is an urgent need to explore novel therapeutic strategies using nanodelivery of drugs and agents either alone or in combination for superior neuroprotection in AD and enhanced quality of life of the affected individuals. There are reports that AD is often associated with diminished neurotrophic factors and neprilysin together with enhancement of phosphorylated Tau (p-Tau) within the brain and in the cerebrospinal fluid (CSF). Thus, studies aiming to enhance neurotrophic factors and neprilysin together with neutralizing p-Tau within the central nervous system (CNS) may alleviate brain pathology in AD. In this review these strategies are discussed using nanotechnological approaches largely based on our own investigations in relation to current literature in the field.

Original language	English (US)
Title of host publication	Nanoneuroprotection and Nanoneurotoxicology
Editors	Aruna Sharma, Hari Shanker Sharma
Publisher	Elsevier B.V.
Pages	145-200
Number of pages	56
ISBN (Print)	9780444642080
DOIs	https://doi.org/10.1016/bs.pbr.2019.03.009
State	Published - Jan 1 2019

Publication series

Name	Progress in Brain Research
Volume	245
ISSN (Print)	0079-6123
ISSN (Electronic)	1875-7855

Funding

Supported by grants from the Air Force Office of Scientific Research (EOARD, London, UK), and Air Force Material Command, USAF, under grant number FA8655-05-1-3065; supported by Grants from the Alzheimer's Association (IIRG-09-132087), the National Institutes of Health (R01 AG028679) and the Dr. Robert M. Kohrman Memorial Fund (MAS, R.J.C.); Swedish Medical Research Council (Nr 2710-H.S.S.), Göran Gustafsson Foundation, Stockholm, Sweden (H.S.S.), Astra Zeneca, Mölndal, Sweden (H.S.S./A.S.), The University Grants Commission, New Delhi, India (H.S.S./A.S.), Ministry of Science & Technology, Govt. India (H.S.S./A.S.), Indian Medical Research Council, New Delhi, India (H.S.S./A.S.) and India-EU Co-operation Program (RP/A.S./H.S.S.) and IT 794/13 (J.V.L.), Government of Basque Country and UFI 11/32 (J.V.L.) University of Basque Country, Spain, & Society for Neuroprotection and Neuroplasticity (SSNN), Romania. Technical and human support provided by Dr. Ricardo Andrade from SGIker (UPV/EHU) is gratefully acknowledged. We thank Suraj Sharma, Uppsala, Sweden for computer and graphic support. The U.S. Government is authorized to reproduce and distribute reprints for Government purpose notwithstanding any copyright notation thereon. The views and conclusions contained herein are those of the authors and should not be interpreted as necessarily representing the official policies or endorsements, either expressed or implied, of the Air Force Office of Scientific Research or the U.S. Government.

Keywords

Alzheimer's disease
Antibodies
Blood-brain barrier
Brain edema
Brain pathology
Cerebrolysin
Nanowired delivery
Neurotrophic factors
Phosphorylated Tau protein

ASJC Scopus subject areas

General Neuroscience

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10.1016/bs.pbr.2019.03.009

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Sharma, H. S., Muresanu, D. F., Castellani, R. J., Nozari, A., Lafuente, J. V., Tian, Z. R., Ozkizilcik, A., Manzhulo, I., Mössler, H., & Sharma, A. (2019). Nanowired delivery of cerebrolysin with neprilysin and p-Tau antibodies induces superior neuroprotection in Alzheimer's disease. In A. Sharma, & H. S. Sharma (Eds.), Nanoneuroprotection and Nanoneurotoxicology (pp. 145-200). (Progress in Brain Research; Vol. 245). Elsevier B.V.. https://doi.org/10.1016/bs.pbr.2019.03.009

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title = "Nanowired delivery of cerebrolysin with neprilysin and p-Tau antibodies induces superior neuroprotection in Alzheimer's disease",

abstract = "Alzheimer's disease (AD) is estimated to be afflicting over 55 millions of individual worldwide in 2018–19 for which no suitable clinical therapeutic measures have been developed so far. Thus, there is an urgent need to explore novel therapeutic strategies using nanodelivery of drugs and agents either alone or in combination for superior neuroprotection in AD and enhanced quality of life of the affected individuals. There are reports that AD is often associated with diminished neurotrophic factors and neprilysin together with enhancement of phosphorylated Tau (p-Tau) within the brain and in the cerebrospinal fluid (CSF). Thus, studies aiming to enhance neurotrophic factors and neprilysin together with neutralizing p-Tau within the central nervous system (CNS) may alleviate brain pathology in AD. In this review these strategies are discussed using nanotechnological approaches largely based on our own investigations in relation to current literature in the field.",

keywords = "Alzheimer's disease, Antibodies, Blood-brain barrier, Brain edema, Brain pathology, Cerebrolysin, Nanowired delivery, Neurotrophic factors, Phosphorylated Tau protein",

author = "Sharma, {Hari Shanker} and Muresanu, {Dafin F.} and Castellani, {Rudy J.} and Ala Nozari and Lafuente, {Jos{\'e} Vicente} and Tian, {Z. Ryan} and Asya Ozkizilcik and Igor Manzhulo and Herbert M{\"o}ssler and Aruna Sharma",

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Sharma, HS, Muresanu, DF, Castellani, RJ, Nozari, A, Lafuente, JV, Tian, ZR, Ozkizilcik, A, Manzhulo, I, Mössler, H & Sharma, A 2019, Nanowired delivery of cerebrolysin with neprilysin and p-Tau antibodies induces superior neuroprotection in Alzheimer's disease. in A Sharma & HS Sharma (eds), Nanoneuroprotection and Nanoneurotoxicology. Progress in Brain Research, vol. 245, Elsevier B.V., pp. 145-200. https://doi.org/10.1016/bs.pbr.2019.03.009

Nanowired delivery of cerebrolysin with neprilysin and p-Tau antibodies induces superior neuroprotection in Alzheimer's disease. / Sharma, Hari Shanker; Muresanu, Dafin F.; Castellani, Rudy J. et al.
Nanoneuroprotection and Nanoneurotoxicology. ed. / Aruna Sharma; Hari Shanker Sharma. Elsevier B.V., 2019. p. 145-200 (Progress in Brain Research; Vol. 245).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

TY - CHAP

T1 - Nanowired delivery of cerebrolysin with neprilysin and p-Tau antibodies induces superior neuroprotection in Alzheimer's disease

AU - Sharma, Hari Shanker

AU - Muresanu, Dafin F.

AU - Castellani, Rudy J.

AU - Nozari, Ala

AU - Lafuente, José Vicente

AU - Tian, Z. Ryan

AU - Ozkizilcik, Asya

AU - Manzhulo, Igor

AU - Mössler, Herbert

AU - Sharma, Aruna

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Alzheimer's disease (AD) is estimated to be afflicting over 55 millions of individual worldwide in 2018–19 for which no suitable clinical therapeutic measures have been developed so far. Thus, there is an urgent need to explore novel therapeutic strategies using nanodelivery of drugs and agents either alone or in combination for superior neuroprotection in AD and enhanced quality of life of the affected individuals. There are reports that AD is often associated with diminished neurotrophic factors and neprilysin together with enhancement of phosphorylated Tau (p-Tau) within the brain and in the cerebrospinal fluid (CSF). Thus, studies aiming to enhance neurotrophic factors and neprilysin together with neutralizing p-Tau within the central nervous system (CNS) may alleviate brain pathology in AD. In this review these strategies are discussed using nanotechnological approaches largely based on our own investigations in relation to current literature in the field.

AB - Alzheimer's disease (AD) is estimated to be afflicting over 55 millions of individual worldwide in 2018–19 for which no suitable clinical therapeutic measures have been developed so far. Thus, there is an urgent need to explore novel therapeutic strategies using nanodelivery of drugs and agents either alone or in combination for superior neuroprotection in AD and enhanced quality of life of the affected individuals. There are reports that AD is often associated with diminished neurotrophic factors and neprilysin together with enhancement of phosphorylated Tau (p-Tau) within the brain and in the cerebrospinal fluid (CSF). Thus, studies aiming to enhance neurotrophic factors and neprilysin together with neutralizing p-Tau within the central nervous system (CNS) may alleviate brain pathology in AD. In this review these strategies are discussed using nanotechnological approaches largely based on our own investigations in relation to current literature in the field.

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KW - Antibodies

KW - Blood-brain barrier

KW - Brain edema

KW - Brain pathology

KW - Cerebrolysin

KW - Nanowired delivery

KW - Neurotrophic factors

KW - Phosphorylated Tau protein

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M3 - Chapter

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SN - 9780444642080

T3 - Progress in Brain Research

SP - 145

EP - 200

BT - Nanoneuroprotection and Nanoneurotoxicology

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PB - Elsevier B.V.

ER -

Sharma HS, Muresanu DF, Castellani RJ, Nozari A, Lafuente JV, Tian ZR et al. Nanowired delivery of cerebrolysin with neprilysin and p-Tau antibodies induces superior neuroprotection in Alzheimer's disease. In Sharma A, Sharma HS, editors, Nanoneuroprotection and Nanoneurotoxicology. Elsevier B.V. 2019. p. 145-200. (Progress in Brain Research). doi: 10.1016/bs.pbr.2019.03.009

Nanowired delivery of cerebrolysin with neprilysin and p-Tau antibodies induces superior neuroprotection in Alzheimer's disease

Abstract

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Funding

Keywords

ASJC Scopus subject areas

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