Narcolepsy type 1 comorbid with myasthenia gravis: possible immunological link

Sally El Sammak; Veronica Cipriani; Ashima Sahni; Hrayr Attarian

doi:10.5664/jcsm.9980

Narcolepsy type 1 comorbid with myasthenia gravis: possible immunological link

Sally El Sammak, Veronica Cipriani, Ashima Sahni, Hrayr Attarian^*

^*Corresponding author for this work

Neurology

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Narcolepsy type 1 (NT1) has a probable autoimmune pathophysiology. Myasthenia gravis (MG) is an auto-antibody-mediated neuromuscular junction disorder. In the case report below we describe 2 women who were diagnosed with NT1 at ages 33 and 46 years, respectively. Both have seronegative MG and, although the MG was diagnosed earlier than the NT1, the symptoms of both conditions in both women started simultaneously. We discuss the potential mechanism linking these 2 conditions and the possibility of early detection of NT1 in patients with MG.

Original language	English (US)
Pages (from-to)	1889-1890
Number of pages	2
Journal	Journal of Clinical Sleep Medicine
Volume	18
Issue number	7
DOIs	https://doi.org/10.5664/jcsm.9980
State	Published - Jul 1 2022

Keywords

Multiple Sleep Latency Test
autoimmunity
myasthenia gravis
narcolepsy type 1
seronegative

ASJC Scopus subject areas

Medicine(all)

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title = "Narcolepsy type 1 comorbid with myasthenia gravis: possible immunological link",

abstract = "Narcolepsy type 1 (NT1) has a probable autoimmune pathophysiology. Myasthenia gravis (MG) is an auto-antibody-mediated neuromuscular junction disorder. In the case report below we describe 2 women who were diagnosed with NT1 at ages 33 and 46 years, respectively. Both have seronegative MG and, although the MG was diagnosed earlier than the NT1, the symptoms of both conditions in both women started simultaneously. We discuss the potential mechanism linking these 2 conditions and the possibility of early detection of NT1 in patients with MG.",

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T1 - Narcolepsy type 1 comorbid with myasthenia gravis

T2 - possible immunological link

AU - El Sammak, Sally

AU - Cipriani, Veronica

AU - Sahni, Ashima

AU - Attarian, Hrayr

PY - 2022/7/1

Y1 - 2022/7/1

N2 - Narcolepsy type 1 (NT1) has a probable autoimmune pathophysiology. Myasthenia gravis (MG) is an auto-antibody-mediated neuromuscular junction disorder. In the case report below we describe 2 women who were diagnosed with NT1 at ages 33 and 46 years, respectively. Both have seronegative MG and, although the MG was diagnosed earlier than the NT1, the symptoms of both conditions in both women started simultaneously. We discuss the potential mechanism linking these 2 conditions and the possibility of early detection of NT1 in patients with MG.

AB - Narcolepsy type 1 (NT1) has a probable autoimmune pathophysiology. Myasthenia gravis (MG) is an auto-antibody-mediated neuromuscular junction disorder. In the case report below we describe 2 women who were diagnosed with NT1 at ages 33 and 46 years, respectively. Both have seronegative MG and, although the MG was diagnosed earlier than the NT1, the symptoms of both conditions in both women started simultaneously. We discuss the potential mechanism linking these 2 conditions and the possibility of early detection of NT1 in patients with MG.

KW - Multiple Sleep Latency Test

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KW - myasthenia gravis

KW - narcolepsy type 1

KW - seronegative

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Narcolepsy type 1 comorbid with myasthenia gravis: possible immunological link

Abstract

Keywords

ASJC Scopus subject areas

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