Narcolepsy type 1 comorbid with myasthenia gravis: possible immunological link

Sally El Sammak, Veronica Cipriani, Ashima Sahni, Hrayr Attarian

Research output: Contribution to journalArticlepeer-review

Abstract

Narcolepsy type 1 (NT1) has a probable autoimmune pathophysiology. Myasthenia gravis (MG) is an auto-antibody-mediated neuromuscular junction disorder. In the case report below we describe 2 women who were diagnosed with NT1 at ages 33 and 46 years, respectively. Both have seronegative MG and, although the MG was diagnosed earlier than the NT1, the symptoms of both conditions in both women started simultaneously. We discuss the potential mechanism linking these 2 conditions and the possibility of early detection of NT1 in patients with MG. CITATION: El Sammak S, Cipriani V, Sahni A, Attarian H. Narcolepsy type 1 comorbid with myasthenia gravis: possible immunological link. J Clin Sleep Med. 2022;18(7):1889-1890.

Original languageEnglish (US)
Pages (from-to)1889-1890
Number of pages2
JournalJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine
Volume18
Issue number7
DOIs
StatePublished - Jul 1 2022

Keywords

  • Multiple Sleep Latency Test
  • autoimmunity
  • myasthenia gravis
  • narcolepsy type 1
  • seronegative

ASJC Scopus subject areas

  • Medicine(all)

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