Narcolepsy with cataplexy as presenting symptom of occult neuroblastoma

Claudine Sinsioco*, Kenneth Silver, Katharine M. Forrest, Juliet Gray, Alla Nechay, Stephen Sheldon, Ewa Chelmicka Schorr

*Corresponding author for this work

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Neuroblastoma associated with the paraneoplastic syndrome of opsoclonus-myoclonus is well-described. However, presentation with narcolepsy-cataplexy is not well-documented in the literature. Narcolepsy with cataplexy is also rare in children younger than 5 years of age. Here we describe three patients, each presenting in early childhood with complex neurological symptoms including narcolepsy with cataplexy that were subsequently found to have paraspinal neuroblastoma. In two of the cases, neurological symptoms resolved with treatment of the tumor and/or immunosuppression, but in one case, the child persistently had a devastating course despite complete resection of the tumor and aggressive immunosuppression.

Original languageEnglish (US)
Pages (from-to)64-67
Number of pages4
JournalPediatric neurology
Volume49
Issue number1
DOIs
StatePublished - Jul 2013

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Neurology
  • Developmental Neuroscience
  • Clinical Neurology

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    Sinsioco, C., Silver, K., Forrest, K. M., Gray, J., Nechay, A., Sheldon, S., & Chelmicka Schorr, E. (2013). Narcolepsy with cataplexy as presenting symptom of occult neuroblastoma. Pediatric neurology, 49(1), 64-67. https://doi.org/10.1016/j.pediatrneurol.2012.12.038