Narcolepsy with cataplexy as presenting symptom of occult neuroblastoma

Claudine Sinsioco; Kenneth Silver; Katharine M. Forrest; Juliet Gray; Alla Nechay; Stephen Sheldon; Ewa Chelmicka Schorr

doi:10.1016/j.pediatrneurol.2012.12.038

Narcolepsy with cataplexy as presenting symptom of occult neuroblastoma

Claudine Sinsioco^*, Kenneth Silver, Katharine M. Forrest, Juliet Gray, Alla Nechay, Stephen Sheldon, Ewa Chelmicka Schorr

^*Corresponding author for this work

Pediatrics

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Neuroblastoma associated with the paraneoplastic syndrome of opsoclonus-myoclonus is well-described. However, presentation with narcolepsy-cataplexy is not well-documented in the literature. Narcolepsy with cataplexy is also rare in children younger than 5 years of age. Here we describe three patients, each presenting in early childhood with complex neurological symptoms including narcolepsy with cataplexy that were subsequently found to have paraspinal neuroblastoma. In two of the cases, neurological symptoms resolved with treatment of the tumor and/or immunosuppression, but in one case, the child persistently had a devastating course despite complete resection of the tumor and aggressive immunosuppression.

Original language	English (US)
Pages (from-to)	64-67
Number of pages	4
Journal	Pediatric neurology
Volume	49
Issue number	1
DOIs	https://doi.org/10.1016/j.pediatrneurol.2012.12.038
State	Published - Jul 2013

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Neurology
Developmental Neuroscience
Clinical Neurology

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10.1016/j.pediatrneurol.2012.12.038

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title = "Narcolepsy with cataplexy as presenting symptom of occult neuroblastoma",

abstract = "Neuroblastoma associated with the paraneoplastic syndrome of opsoclonus-myoclonus is well-described. However, presentation with narcolepsy-cataplexy is not well-documented in the literature. Narcolepsy with cataplexy is also rare in children younger than 5 years of age. Here we describe three patients, each presenting in early childhood with complex neurological symptoms including narcolepsy with cataplexy that were subsequently found to have paraspinal neuroblastoma. In two of the cases, neurological symptoms resolved with treatment of the tumor and/or immunosuppression, but in one case, the child persistently had a devastating course despite complete resection of the tumor and aggressive immunosuppression.",

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T1 - Narcolepsy with cataplexy as presenting symptom of occult neuroblastoma

AU - Sinsioco, Claudine

AU - Silver, Kenneth

AU - Forrest, Katharine M.

AU - Gray, Juliet

AU - Nechay, Alla

AU - Sheldon, Stephen

AU - Chelmicka Schorr, Ewa

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N2 - Neuroblastoma associated with the paraneoplastic syndrome of opsoclonus-myoclonus is well-described. However, presentation with narcolepsy-cataplexy is not well-documented in the literature. Narcolepsy with cataplexy is also rare in children younger than 5 years of age. Here we describe three patients, each presenting in early childhood with complex neurological symptoms including narcolepsy with cataplexy that were subsequently found to have paraspinal neuroblastoma. In two of the cases, neurological symptoms resolved with treatment of the tumor and/or immunosuppression, but in one case, the child persistently had a devastating course despite complete resection of the tumor and aggressive immunosuppression.

AB - Neuroblastoma associated with the paraneoplastic syndrome of opsoclonus-myoclonus is well-described. However, presentation with narcolepsy-cataplexy is not well-documented in the literature. Narcolepsy with cataplexy is also rare in children younger than 5 years of age. Here we describe three patients, each presenting in early childhood with complex neurological symptoms including narcolepsy with cataplexy that were subsequently found to have paraspinal neuroblastoma. In two of the cases, neurological symptoms resolved with treatment of the tumor and/or immunosuppression, but in one case, the child persistently had a devastating course despite complete resection of the tumor and aggressive immunosuppression.

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Narcolepsy with cataplexy as presenting symptom of occult neuroblastoma

Abstract

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