Objective To describe a patient wtih dermatofibrosarcoma protuberans causing a nasolacrimal duct obstruction (NLDO). Design Case report. Participant A 33-year-old female with an NLDO. Results We report a patient with NLDO as the presenting sign of a rare tumor of the skin, dermatofibrosarcoma protuberans. The patient presented with epiphora, and after dacryocystorhinostomy was done, histopathology revealed dermatofibrosarcoma protuberans. The clinical course, magnetic resonance imaging, and histopathology are discussed. Conclusion Obstruction of the lacrimal drainage system can be seen with dermatofibrosarcoma protuberans.
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