Native BK viral nephropathy in a pediatric heart transplant recipient

Farah N. Ali, Shane M. Meehan, Elfriede Pahl, Richard A. Cohn

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

BK viral nephropathy is a well-documented clinical entity in kidney transplant recipients and a significant cause of morbidity and allograft loss in affected patients. BK viral nephropathy in native kidneys of non-kidney transplant recipients is relatively uncommon, but has been reported in adult patients. We report the occurrence of BK viral nephropathy in a pediatric heart transplant recipient. A 10-yr-old boy with past history of Ewing's sarcoma underwent heart transplantation for dilated cardiomyopathy induced by previous chemotherapy with doxorubicin. Post-transplant course was complicated by grade 3A rejection and CMV colitis. He was diagnosed with native BK viral nephropathy approximately 18 months post-transplant due to mild, but persistent, elevation in serum creatinine associated with proteinuria. BK viral nephropathy affects non-kidney transplant recipients, and a high index of suspicion is necessary for early diagnosis and management of this condition.

Original languageEnglish (US)
Pages (from-to)E38-E41
JournalPediatric transplantation
Volume14
Issue number4
DOIs
StatePublished - Jun 2010

Keywords

  • BK virus
  • Pediatric transplantation
  • Polyomavirus nephropathy
  • Post-transplant infection
  • Viremia

ASJC Scopus subject areas

  • Transplantation
  • Pediatrics, Perinatology, and Child Health

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