Native BK viral nephropathy in a pediatric heart transplant recipient

Farah N. Ali, Shane M. Meehan, Elfriede Pahl, Richard A Cohn

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

BK viral nephropathy is a well-documented clinical entity in kidney transplant recipients and a significant cause of morbidity and allograft loss in affected patients. BK viral nephropathy in native kidneys of non-kidney transplant recipients is relatively uncommon, but has been reported in adult patients. We report the occurrence of BK viral nephropathy in a pediatric heart transplant recipient. A 10-yr-old boy with past history of Ewing's sarcoma underwent heart transplantation for dilated cardiomyopathy induced by previous chemotherapy with doxorubicin. Post-transplant course was complicated by grade 3A rejection and CMV colitis. He was diagnosed with native BK viral nephropathy approximately 18 months post-transplant due to mild, but persistent, elevation in serum creatinine associated with proteinuria. BK viral nephropathy affects non-kidney transplant recipients, and a high index of suspicion is necessary for early diagnosis and management of this condition.

Original languageEnglish (US)
JournalPediatric Transplantation
Volume14
Issue number4
DOIs
StatePublished - Jun 1 2010

Fingerprint

Pediatrics
Transplants
Kidney
Ewing's Sarcoma
Dilated Cardiomyopathy
Colitis
Heart Transplantation
Proteinuria
Doxorubicin
Allografts
Early Diagnosis
Creatinine
Morbidity
Drug Therapy
Transplant Recipients
Serum

Keywords

  • BK virus
  • Pediatric transplantation
  • Polyomavirus nephropathy
  • Post-transplant infection
  • Viremia

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Transplantation

Cite this

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Native BK viral nephropathy in a pediatric heart transplant recipient. / Ali, Farah N.; Meehan, Shane M.; Pahl, Elfriede; Cohn, Richard A.

In: Pediatric Transplantation, Vol. 14, No. 4, 01.06.2010.

Research output: Contribution to journalArticle

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AU - Ali, Farah N.

AU - Meehan, Shane M.

AU - Pahl, Elfriede

AU - Cohn, Richard A

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AB - BK viral nephropathy is a well-documented clinical entity in kidney transplant recipients and a significant cause of morbidity and allograft loss in affected patients. BK viral nephropathy in native kidneys of non-kidney transplant recipients is relatively uncommon, but has been reported in adult patients. We report the occurrence of BK viral nephropathy in a pediatric heart transplant recipient. A 10-yr-old boy with past history of Ewing's sarcoma underwent heart transplantation for dilated cardiomyopathy induced by previous chemotherapy with doxorubicin. Post-transplant course was complicated by grade 3A rejection and CMV colitis. He was diagnosed with native BK viral nephropathy approximately 18 months post-transplant due to mild, but persistent, elevation in serum creatinine associated with proteinuria. BK viral nephropathy affects non-kidney transplant recipients, and a high index of suspicion is necessary for early diagnosis and management of this condition.

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