TY - JOUR
T1 - Natriuretic peptides in the central nervous system
T2 - Novel targets for cognitive impairment
AU - Mahinrad, Simin
AU - de Craen, Anton J.M.
AU - Yasar, Sevil
AU - van Heemst, Diana
AU - Sabayan, Behnam
N1 - Funding Information:
This work is supported by the European Community within the Seventh Framework Program under grant agreement no. Health-F2-2010-259772 (Switchbox). B. Sabayan is partly supported by a grant from Internationale Stichting Alzheimer Onderzoek (ISAO) .
Publisher Copyright:
© 2016 Elsevier Ltd.
PY - 2016/9/1
Y1 - 2016/9/1
N2 - Natriuretic peptides (NPs) are traditionally known as cardiac hormones with diuretic, natriuretic and blood pressure lowering properties. Evidence indicates that NPs and their receptors are abundant in the central nervous system, suggesting their involvement in regulation of various brain functions. It has been shown that NPs are involved in the regulation of neurovascular and blood-brain barrier integrity, neuro-inflammation, neuroprotection, synaptic transmission and brain fluid homeostasis. In addition, NPs might contribute to the brain's inhibitory control over the hypothalamic-pituitary-adrenal axis. Studies have also shown that high systemic levels of NPs are associated with cognitive impairment independent of cardiovascular risk factors. In this review we discuss the potential roles of NPs in regulating structural and functional integrity of the brain. Based on the available neurobiological and clinical evidence, we propose that NPs might represent as potential novel diagnostic and therapeutic targets for cognitive impairment.
AB - Natriuretic peptides (NPs) are traditionally known as cardiac hormones with diuretic, natriuretic and blood pressure lowering properties. Evidence indicates that NPs and their receptors are abundant in the central nervous system, suggesting their involvement in regulation of various brain functions. It has been shown that NPs are involved in the regulation of neurovascular and blood-brain barrier integrity, neuro-inflammation, neuroprotection, synaptic transmission and brain fluid homeostasis. In addition, NPs might contribute to the brain's inhibitory control over the hypothalamic-pituitary-adrenal axis. Studies have also shown that high systemic levels of NPs are associated with cognitive impairment independent of cardiovascular risk factors. In this review we discuss the potential roles of NPs in regulating structural and functional integrity of the brain. Based on the available neurobiological and clinical evidence, we propose that NPs might represent as potential novel diagnostic and therapeutic targets for cognitive impairment.
KW - Central nervous system
KW - Cognitive impairment
KW - Natriuretic peptides
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U2 - 10.1016/j.neubiorev.2016.05.022
DO - 10.1016/j.neubiorev.2016.05.022
M3 - Review article
C2 - 27229760
AN - SCOPUS:84971618276
SN - 0149-7634
VL - 68
SP - 148
EP - 156
JO - Neuroscience and Biobehavioral Reviews
JF - Neuroscience and Biobehavioral Reviews
ER -