Abstract
Thirteen children with systemic lupus erythematosus (SLE) and 5 with juvenile dermatomyositis (JDM) were studied for natural cytotoxicity (NK) and antibody-dependent cellular cytotoxicity (ADCC). In vitro prednisolone at pharmacological levels failed to alter NK or ADCC in adult controls, nor did it alter ADCC in any children studied. ADCC was normal, but NK was decreased in SLE (p < .005) and JDM (p < .05) compared to controls. Since NK but not ADCC is decreased in these patients, different lymphocyte populations may indicate these 2 cytotoxic functions.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 640-642 |
| Number of pages | 3 |
| Journal | Journal of Rheumatology |
| Volume | 10 |
| Issue number | 4 |
| State | Published - Dec 1 1983 |
ASJC Scopus subject areas
- Immunology
- Rheumatology