Natural and antibody-dependent cellular cytotoxicity in children with systemic lupus erythematosus and juvenile dermatomyositis

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17 Scopus citations

Abstract

Thirteen children with systemic lupus erythematosus (SLE) and 5 with juvenile dermatomyositis (JDM) were studied for natural cytotoxicity (NK) and antibody-dependent cellular cytotoxicity (ADCC). In vitro prednisolone at pharmacological levels failed to alter NK or ADCC in adult controls, nor did it alter ADCC in any children studied. ADCC was normal, but NK was decreased in SLE (p < .005) and JDM (p < .05) compared to controls. Since NK but not ADCC is decreased in these patients, different lymphocyte populations may indicate these 2 cytotoxic functions.

Original languageEnglish (US)
Pages (from-to)640-642
Number of pages3
JournalJournal of Rheumatology
Volume10
Issue number4
StatePublished - Dec 1 1983

ASJC Scopus subject areas

  • Immunology
  • Rheumatology

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