NCCN task force report: Update on the management of patients with gastrointestinal stromal tumors

George D. Demetri, Margaret Von Mehren, Cristina R. Antonescu, Ronald P. DeMatteo, Kristen N. Ganjoo, Robert G. Maki, Peter W T Pisters, Chandrajit P. Raut, Richard F. Riedel, Scott Schuetze, Hema M. Sundar, Jonathan C. Trent, Jeffrey D. Wayne

Research output: Contribution to journalReview articlepeer-review

759 Scopus citations


The standard of care for managing patients with gastrointestinal stromal tumors (GISTs) rapidly changed after the introduction of effective molecularly targeted therapies involving tyrosine kinase inhibitors (TKIs), such as imatinib mesylate and sunitinib malate. A better understanding of the molecular characteristics of GISTs have improved the diagnostic accuracy and led to the discovery of novel immunomarkers and new mechanisms of resistance to TKI therapy, which in turn have resulted in the development of novel treatment strategies. To address these issues, the NCCN organized a task force consisting of a multidisciplinary panel of experts in the fields of medical oncology, surgical oncology, molecular diagnostics, and pathology to discuss the recent advances, identify areas of future research, and recommend an optimal approach to care for patients with GIST at all stages of disease. The task force met for the first time in October 2003 and again in December 2006 and October 2009. This supplement describes the recent developments in the field of GIST as discussed at the October 2009 meeting.

Original languageEnglish (US)
Pages (from-to)S1-S40
JournalJNCCN Journal of the National Comprehensive Cancer Network
Issue numberSUPPL. 2
StatePublished - Apr 2010


  • Abdominal tumor
  • CD117
  • GEP
  • GIST
  • Gastric mass
  • Gastrointestinal stromal tumor
  • Gastrointestinal tract
  • Gene expression profiling
  • Imatinib
  • KIT
  • Liver metastasis
  • NCCN
  • Small bowel tumor
  • Stomach cancer
  • Sunitinib
  • TKIs
  • Tyrosine kinase inhibitors
  • Wild-type GISTs

ASJC Scopus subject areas

  • Oncology


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