Near-Infrared Fluorescent Endoscopic Image-Guided Photothermal Ablation Therapy of Colorectal Cancer Using Dual-Modal Gold Nanorods Targeting Tumor-Infiltrating Innate Immune Cells in a Transgenic TS4 CRE/APCloxÎ"468 Mouse Model

Elias Gournaris, Wooram Park, Soojeong Cho, David J. Bentrem, Andrew C. Larson, Dong Hyun Kim*

*Corresponding author for this work

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Colorectal cancer (CRC) is diagnosed with colonoscopy and treated with focal therapies. CRC is a good candidate for nanoparticle-mediated photothermal ablation (PTA) therapy. Herein, we developed a near-infrared fluorescent (NIRF) endoscopic image-guided PTA approach using a nanoparticle capable of simultaneously diagnosing and treating CRC. Dual-modal NIR heating and fluorescent gold nanorods (dual-modal GNRs) were synthesized by conjugation of GNRs to an NIRF probe. To validate the translational potential of our approach, a well-characterized transgenic TS4 CRE/APCloxÎ"468 colon cancer mouse model was used to carry out NIRF image-guided PTA using our dual-modal GNRs under clinically relevant conditions. Intravenously infused dual-modal GNRs were effectively targeted at colon polyps by immunogenic capturing of the GNRs within tumor-infiltrating innate immune cells. NIRF endoscopic image-guided PTA using the GNRs permitted successful detection and ablation of inflammatory colon polyps. NIRF endoscopy image-guided PTA using dual-modal GNRs can be utilized for diagnosis and treatment of CRC and various inflammatory diseases.

Original languageEnglish (US)
Pages (from-to)21353-21359
Number of pages7
JournalACS Applied Materials and Interfaces
Volume11
Issue number24
DOIs
StatePublished - Jun 19 2019

Keywords

  • colon cancer
  • endoscopic image-guided therapy
  • interventional oncology
  • nanomedicine
  • photothermal therapy

ASJC Scopus subject areas

  • Materials Science(all)

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