Near-infrared light photoacoustic ophthalmoscopy

Tan Liu, Qing Wei, Wei Song, Janice M. Burke, Shuliang Jiao, Hao F. Zhang

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

We achieved photoacoustic ophthalmoscopy (PAOM) imaging of the retina with near-infrared (NIR) light illumination. A PAOM imaging system with dual-wavelength illumination at 1064 nm and 532 nm was built. We compared in vivo imaging results of both albino and pigmented rat eyes at the two wavelengths. The results show that the bulk optical absorption of the retinal pigment epithelium (RPE) is only slightly higher than that of the retinal vessels at 532 nm while it becomes more than an order of magnitude higher than that of the retinal vessels at 1064 nm. These studies suggest that although visible light illumination is suitable for imaging both the retinal vessels and the RPE, NIR light illumination, being more comfortable to the eye, is better suited for RPE melanin related investigations and diagnoses.

Original languageEnglish (US)
Pages (from-to)792-799
Number of pages8
JournalBiomedical Optics Express
Volume3
Issue number4
DOIs
StatePublished - Apr 1 2012

ASJC Scopus subject areas

  • Biotechnology
  • Atomic and Molecular Physics, and Optics

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