Necrosis of carcinoma cells using Co1-xNixFe 2O4 and Ba1-xSrxFe 12O19 ferrites under alternating magnetic field

Dong Hyun Kim; Kyoung Nam Kim; Kwang Mahn Kim; In Bo Shim; Yong Keun Lee

doi:10.1109/TMAG.2004.829181

Necrosis of carcinoma cells using Co_1-xNi_xFe ₂O₄ and Ba_1-xSr_xFe ₁₂O₁₉ ferrites under alternating magnetic field

Dong Hyun Kim^*, Kyoung Nam Kim, Kwang Mahn Kim, In Bo Shim, Yong Keun Lee

^*Corresponding author for this work

Radiology

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

The purpose of this study was to investigate the cell necrosis by the hysteric heating of Co_1-xNi_xFe₂O₄ and Ba_1-xSr_xFe₁₂O₁₉ ferrites under external magnetic field with respect to applications in hyperthermic cancer treatments. Co_1-xNi_xFe₂O₄ and Ba_1-xSr_xFe₁₂O₁₉ ferrites were synthesized by a sol-gel process. Variation of the temperature as a result of hysteresis heating was measured as a function of the exposure time to the external alternating magnetic field at frequencies of 0.1 - ~ 15 MHz. A human squamous cell carcinoma KB cell line was selected to determine the effect of the synthesized ferrites on the destruction of carcinoma cells in vitro using a methylthiazol tetrazolium bromide (MTT) method. When a CoFe₂O ₄ disc was placed in 0.2 ml of distilled water, the greatest temperature change (ΔT = 29.3°C) was observed. More than half of the malignant carcinoma cells were dead after being exposed to the 7-MHz ac magnetic field for 1 h by CoFe₂O₄ ferrites, while normal cells survived more than 60% of the time.

Original language	English (US)
Pages (from-to)	2985-2987
Number of pages	3
Journal	IEEE Transactions on Magnetics
Volume	40
Issue number	4 II
DOIs	https://doi.org/10.1109/TMAG.2004.829181
State	Published - Jul 2004

Keywords

Alternating magnetic field
Carcinoma cell
Hyper-thermia
Hysteresis heating

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Electrical and Electronic Engineering

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1109/TMAG.2004.829181

Cite this

@article{5183ba6a1e3447cba77404e01fa4cd9d,

title = "Necrosis of carcinoma cells using Co1-xNixFe 2O4 and Ba1-xSrxFe 12O19 ferrites under alternating magnetic field",

abstract = "The purpose of this study was to investigate the cell necrosis by the hysteric heating of Co1-xNixFe2O4 and Ba1-xSrxFe12O19 ferrites under external magnetic field with respect to applications in hyperthermic cancer treatments. Co1-xNixFe2O4 and Ba1-xSrxFe12O19 ferrites were synthesized by a sol-gel process. Variation of the temperature as a result of hysteresis heating was measured as a function of the exposure time to the external alternating magnetic field at frequencies of 0.1 - ~ 15 MHz. A human squamous cell carcinoma KB cell line was selected to determine the effect of the synthesized ferrites on the destruction of carcinoma cells in vitro using a methylthiazol tetrazolium bromide (MTT) method. When a CoFe2O 4 disc was placed in 0.2 ml of distilled water, the greatest temperature change (ΔT = 29.3°C) was observed. More than half of the malignant carcinoma cells were dead after being exposed to the 7-MHz ac magnetic field for 1 h by CoFe2O4 ferrites, while normal cells survived more than 60% of the time.",

keywords = "Alternating magnetic field, Carcinoma cell, Hyper-thermia, Hysteresis heating",

author = "Kim, {Dong Hyun} and Kim, {Kyoung Nam} and Kim, {Kwang Mahn} and Shim, {In Bo} and Lee, {Yong Keun}",

note = "Funding Information: Manuscript received October 16, 2003. This work was supported by Grant R01-2001-000-00157 from the Basic Research Program of the Korea Science and Engineering Foundation.",

year = "2004",

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T1 - Necrosis of carcinoma cells using Co1-xNixFe 2O4 and Ba1-xSrxFe 12O19 ferrites under alternating magnetic field

AU - Kim, Dong Hyun

AU - Kim, Kyoung Nam

AU - Kim, Kwang Mahn

AU - Shim, In Bo

AU - Lee, Yong Keun

N1 - Funding Information: Manuscript received October 16, 2003. This work was supported by Grant R01-2001-000-00157 from the Basic Research Program of the Korea Science and Engineering Foundation.

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N2 - The purpose of this study was to investigate the cell necrosis by the hysteric heating of Co1-xNixFe2O4 and Ba1-xSrxFe12O19 ferrites under external magnetic field with respect to applications in hyperthermic cancer treatments. Co1-xNixFe2O4 and Ba1-xSrxFe12O19 ferrites were synthesized by a sol-gel process. Variation of the temperature as a result of hysteresis heating was measured as a function of the exposure time to the external alternating magnetic field at frequencies of 0.1 - ~ 15 MHz. A human squamous cell carcinoma KB cell line was selected to determine the effect of the synthesized ferrites on the destruction of carcinoma cells in vitro using a methylthiazol tetrazolium bromide (MTT) method. When a CoFe2O 4 disc was placed in 0.2 ml of distilled water, the greatest temperature change (ΔT = 29.3°C) was observed. More than half of the malignant carcinoma cells were dead after being exposed to the 7-MHz ac magnetic field for 1 h by CoFe2O4 ferrites, while normal cells survived more than 60% of the time.

AB - The purpose of this study was to investigate the cell necrosis by the hysteric heating of Co1-xNixFe2O4 and Ba1-xSrxFe12O19 ferrites under external magnetic field with respect to applications in hyperthermic cancer treatments. Co1-xNixFe2O4 and Ba1-xSrxFe12O19 ferrites were synthesized by a sol-gel process. Variation of the temperature as a result of hysteresis heating was measured as a function of the exposure time to the external alternating magnetic field at frequencies of 0.1 - ~ 15 MHz. A human squamous cell carcinoma KB cell line was selected to determine the effect of the synthesized ferrites on the destruction of carcinoma cells in vitro using a methylthiazol tetrazolium bromide (MTT) method. When a CoFe2O 4 disc was placed in 0.2 ml of distilled water, the greatest temperature change (ΔT = 29.3°C) was observed. More than half of the malignant carcinoma cells were dead after being exposed to the 7-MHz ac magnetic field for 1 h by CoFe2O4 ferrites, while normal cells survived more than 60% of the time.

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