Needle-shaped ultrathin piezoelectric microsystem for guided tissue targeting via mechanical sensing

Xinge Yu, Heling Wang, Xin Ning, Rujie Sun, Hassan Albadawi, Marcela Salomao, Alvin C. Silva, Yang Yu, Limei Tian, Ahyeon Koh, Chan Mi Lee, Aditya Chempakasseril, Peilin Tian, Matt Pharr, Jianghong Yuan, Yonggang Huang*, Rahmi Oklu, John A. Rogers

*Corresponding author for this work

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Needles for percutaneous biopsies of tumour tissue can be guided by ultrasound or computed tomography. However, despite best imaging practices and operator experience, high rates of inadequate tissue sampling, especially for small lesions, are common. Here, we introduce a needle-shaped ultrathin piezoelectric microsystem that can be injected or mounted directly onto conventional biopsy needles and used to distinguish abnormal tissue during the capture of biopsy samples, through quantitative real-time measurements of variations in tissue modulus. Using well-characterized synthetic soft materials, explanted tissues and animal models, we establish experimentally and theoretically the fundamental operating principles of the microsystem, as well as key considerations in materials choices and device designs. Through systematic tests on human livers with cancerous lesions, we demonstrate that the piezoelectric microsystem provides quantitative agreement with magnetic resonance elastography, the clinical gold standard for the measurement of tissue modulus. The piezoelectric microsystem provides a foundation for the design of tools for the rapid, modulus-based characterization of tissues.

Original languageEnglish (US)
Pages (from-to)165-172
Number of pages8
JournalNature Biomedical Engineering
Volume2
Issue number3
DOIs
StatePublished - Mar 1 2018

Fingerprint

Microsystems
Needles
Tissue
Biopsy
Needle Biopsy
Equipment Design
Elasticity Imaging Techniques
Magnetic resonance
Time measurement
Practice Guidelines
Liver
Tomography
Mathematical operators
Tumors
Animals
Animal Models
Ultrasonics
Sampling
Imaging techniques
Neoplasms

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Medicine (miscellaneous)
  • Biomedical Engineering
  • Computer Science Applications

Cite this

Yu, Xinge ; Wang, Heling ; Ning, Xin ; Sun, Rujie ; Albadawi, Hassan ; Salomao, Marcela ; Silva, Alvin C. ; Yu, Yang ; Tian, Limei ; Koh, Ahyeon ; Lee, Chan Mi ; Chempakasseril, Aditya ; Tian, Peilin ; Pharr, Matt ; Yuan, Jianghong ; Huang, Yonggang ; Oklu, Rahmi ; Rogers, John A. / Needle-shaped ultrathin piezoelectric microsystem for guided tissue targeting via mechanical sensing. In: Nature Biomedical Engineering. 2018 ; Vol. 2, No. 3. pp. 165-172.
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author = "Xinge Yu and Heling Wang and Xin Ning and Rujie Sun and Hassan Albadawi and Marcela Salomao and Silva, {Alvin C.} and Yang Yu and Limei Tian and Ahyeon Koh and Lee, {Chan Mi} and Aditya Chempakasseril and Peilin Tian and Matt Pharr and Jianghong Yuan and Yonggang Huang and Rahmi Oklu and Rogers, {John A.}",
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Yu, X, Wang, H, Ning, X, Sun, R, Albadawi, H, Salomao, M, Silva, AC, Yu, Y, Tian, L, Koh, A, Lee, CM, Chempakasseril, A, Tian, P, Pharr, M, Yuan, J, Huang, Y, Oklu, R & Rogers, JA 2018, 'Needle-shaped ultrathin piezoelectric microsystem for guided tissue targeting via mechanical sensing', Nature Biomedical Engineering, vol. 2, no. 3, pp. 165-172. https://doi.org/10.1038/s41551-018-0201-6

Needle-shaped ultrathin piezoelectric microsystem for guided tissue targeting via mechanical sensing. / Yu, Xinge; Wang, Heling; Ning, Xin; Sun, Rujie; Albadawi, Hassan; Salomao, Marcela; Silva, Alvin C.; Yu, Yang; Tian, Limei; Koh, Ahyeon; Lee, Chan Mi; Chempakasseril, Aditya; Tian, Peilin; Pharr, Matt; Yuan, Jianghong; Huang, Yonggang; Oklu, Rahmi; Rogers, John A.

In: Nature Biomedical Engineering, Vol. 2, No. 3, 01.03.2018, p. 165-172.

Research output: Contribution to journalArticle

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AU - Yu, Xinge

AU - Wang, Heling

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AU - Albadawi, Hassan

AU - Salomao, Marcela

AU - Silva, Alvin C.

AU - Yu, Yang

AU - Tian, Limei

AU - Koh, Ahyeon

AU - Lee, Chan Mi

AU - Chempakasseril, Aditya

AU - Tian, Peilin

AU - Pharr, Matt

AU - Yuan, Jianghong

AU - Huang, Yonggang

AU - Oklu, Rahmi

AU - Rogers, John A.

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