Negative regulatory effects of Mnk kinases in the generation of chemotherapy-induced antileukemic responses

Keyphrases

• Regulatory Effect 100%
• Antileukemic Activity 100%
• Chemotherapy-induced 100%
• Cytarabine 100%
• Eukaryotic Translation Initiation Factor 4E (eIF4E) 80%
• Phosphorylation 60%
• Pharmacological Inhibitors 60%
• Leukemia 40%
• Acute Myeloid Leukemia 40%
• Small Interfering RNA (siRNA) 40%
• Knockdown 40%
• MTOR Inhibitor 40%
• RNA-based 40%
• MNK1 40%
• Mitogen-activated Protein Kinase 20%
• Hematopoietic Stem Cells 20%
• Colony Forming Units 20%
• Acute Myeloid Leukemia Cells 20%
• Downstream Effectors 20%
• Functional Relevance 20%
• Immunoblotting 20%
• Rapamycin 20%
• Activation Status 20%
• Suppression Effect 20%
• Response to Chemotherapy 20%
• Targeted Disruption 20%
• MNK2 20%
• Eukaryotic Initiation Factor 20%
• Concomitant Treatment 20%
• Negative Feedback 20%
• Phosphorylation Reaction 20%
• Apoptosis Assay 20%
• Methylcellulose 20%
• Clonogenic 20%

Pharmacology, Toxicology and Pharmaceutical Science

• Chemotherapy 100%
• Cytarabine 100%
• Initiation Factor 4E 80%
• Acute Myeloid Leukemia 60%
• Small Interfering RNA 40%
• Mammalian Target of Rapamycin Inhibitor 40%
• Western Blot 20%
• Apoptosis Assay 20%
• Mitogen Activated Protein Kinase 20%
• Methylcellulose 20%
• Rapamycin 20%
• Messenger RNA 20%

Biochemistry, Genetics and Molecular Biology

• Cytarabine 100%
• Myeloid 60%
• Small Interfering RNA 40%
• Colony Forming Unit S 40%
• Mechanistic Target of Rapamycin 40%
• Product Inhibition 20%
• Eukaryotic Initiation Factor 20%
• Apoptosis Assay 20%
• RNA Translation 20%
• Mitogen-Activated Protein Kinase 20%
• Immunoblotting 20%
• Methyl Cellulose 20%