Neighborhood Socioeconomic Deprivation in Young Adulthood and Future Respiratory Health: The CARDIA Lung Study

Sneha Thatipelli; Kiarri N. Kershaw; Laura A. Colangelo; Penny Gordon-Larsen; David R. Jacobs; Mark T. Dransfield; Daniel Meza; Sharon R. Rosenberg; George R. Washko; Trisha M. Parekh; Mercedes R. Carnethon; Ravi Kalhan

doi:10.1016/j.amjmed.2021.07.048

Neighborhood Socioeconomic Deprivation in Young Adulthood and Future Respiratory Health: The CARDIA Lung Study

Sneha Thatipelli, Kiarri N. Kershaw, Laura A. Colangelo, Penny Gordon-Larsen, David R. Jacobs, Mark T. Dransfield, Daniel Meza, Sharon R. Rosenberg, George R. Washko, Trisha M. Parekh, Mercedes R. Carnethon, Ravi Kalhan^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Purpose: There are limited data on the relationship between neighborhood level factors and their association with lung health independent of individual socioeconomic status. We sought to determine whether baseline neighborhood level socioeconomic deprivation in young adults is associated with greater 20-year decline in lung function and higher risk of future lung disease, independent of baseline individual income, education, and smoking status. Methods: This multicenter population-based cohort study included 2689 participants in Coronary Artery Risk Development in Young Adults (CARDIA) for whom neighborhood deprivation was determined at year 10 (baseline for study) and who had complete lung function measurements at years 10 and 30. Baseline neighborhood deprivation was defined using 1990 Census blocks as a combination of 4 factors involving median household income, poverty level, and educational achievement. The outcomes were decline in lung function over 20 years (year 10 to 30) and odds of emphysema (year 25). Results: In multivariable regression models, greater baseline neighborhood deprivation was associated with greater decline in lung function (−2.34 mL/year excess annual decline in forced expiratory volume in 1 second (FEV₁) in the highest versus lowest deprivation quartile (P =.014)). Furthermore, baseline neighborhood deprivation was independently associated with greater odds of emphysema (odds ratio [OR] 2.99, 95% confidence interval [CI] 1.42-6.30). Conclusions: Residence in neighborhoods with greater socioeconomic deprivation in young adulthood, independent of individual income and smoking, is associated with greater 20-year decline in forced expiratory volume in 1 second and higher risk of future emphysema.

Original language	English (US)
Pages (from-to)	211-218.e1
Journal	American journal of medicine
Volume	135
Issue number	2
DOIs	https://doi.org/10.1016/j.amjmed.2021.07.048
State	Published - Feb 2022

Funding

Funding: The CARDIA Lung study is funded by NHLBI (R01 HL122477). The Coronary Artery Risk Development in Young Adults Study (CARDIA) is conducted and supported by the National Heart, Lung, and Blood Institute (NHLBI) in collaboration with the University of Alabama at Birmingham (HHSN268201800005I and HHSN268201800007I), Northwestern University (HHSN268201800003I), University of Minnesota (HHSN268201800006I), and Kaiser Foundation Research Institute (HHSN268201800004I). This manuscript has been reviewed by CARDIA for scientific content. Conflicts of Interest: ST, KNK, LAC, PG-L, DRJ, DM, TMP, MRC report none. MTD reports grants from the American Lung Association, National Institutes of Health (NIH), and Department of Defense and personal fees from AstraZeneca, GlaxoSmithKline, PulmonX, and Teva. SRR reports grants from the National Institutes of Health (NIH), American Lung Association, and AstraZeneca; personal fees from GlaxoSmithKline; and being a GSK Nucala speaker; AZ biologics in COPD study investigator, NICH PRECisE investigator, and an ACRC investigator. GRW reports grants from National Institutes of Health (NIH), Boehringer Ingelheim, BTG Interventional Medicine, and Janssen Pharmaceuticals; personal fees from Boehringer Ingelheim, Janssen Pharmaceuticals, PulmonX, Novartis, Philips, Vertex, and is a cofounder and equity share holder of Quantitative Imaging Solutions; his spouse is an employee of Biogen. RK reports grants from the National Institutes of Health (NIH) and American Lung association, and personal fees from AstraZeneca, GlaxoSmithKline, and CVS Caremark. Funding: The CARDIA Lung study is funded by NHLBI (R01 HL122477). The Coronary Artery Risk Development in Young Adults Study (CARDIA) is conducted and supported by the National Heart, Lung, and Blood Institute (NHLBI) in collaboration with the University of Alabama at Birmingham (HHSN268201800005I and HHSN268201800007I), Northwestern University (HHSN268201800003I), University of Minnesota (HHSN268201800006I), and Kaiser Foundation Research Institute (HHSN268201800004I). This manuscript has been reviewed by CARDIA for scientific content.

Keywords

Lung disease
Population characteristics
Population health
Public health

ASJC Scopus subject areas

General Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.amjmed.2021.07.048

Cite this

Thatipelli, S., Kershaw, K. N., Colangelo, L. A., Gordon-Larsen, P., Jacobs, D. R., Dransfield, M. T., Meza, D., Rosenberg, S. R., Washko, G. R., Parekh, T. M., Carnethon, M. R., & Kalhan, R. (2022). Neighborhood Socioeconomic Deprivation in Young Adulthood and Future Respiratory Health: The CARDIA Lung Study. American journal of medicine, 135(2), 211-218.e1. https://doi.org/10.1016/j.amjmed.2021.07.048

@article{9726eaef2ab94852a545db330101a217,

title = "Neighborhood Socioeconomic Deprivation in Young Adulthood and Future Respiratory Health: The CARDIA Lung Study",

abstract = "Purpose: There are limited data on the relationship between neighborhood level factors and their association with lung health independent of individual socioeconomic status. We sought to determine whether baseline neighborhood level socioeconomic deprivation in young adults is associated with greater 20-year decline in lung function and higher risk of future lung disease, independent of baseline individual income, education, and smoking status. Methods: This multicenter population-based cohort study included 2689 participants in Coronary Artery Risk Development in Young Adults (CARDIA) for whom neighborhood deprivation was determined at year 10 (baseline for study) and who had complete lung function measurements at years 10 and 30. Baseline neighborhood deprivation was defined using 1990 Census blocks as a combination of 4 factors involving median household income, poverty level, and educational achievement. The outcomes were decline in lung function over 20 years (year 10 to 30) and odds of emphysema (year 25). Results: In multivariable regression models, greater baseline neighborhood deprivation was associated with greater decline in lung function (−2.34 mL/year excess annual decline in forced expiratory volume in 1 second (FEV1) in the highest versus lowest deprivation quartile (P =.014)). Furthermore, baseline neighborhood deprivation was independently associated with greater odds of emphysema (odds ratio [OR] 2.99, 95% confidence interval [CI] 1.42-6.30). Conclusions: Residence in neighborhoods with greater socioeconomic deprivation in young adulthood, independent of individual income and smoking, is associated with greater 20-year decline in forced expiratory volume in 1 second and higher risk of future emphysema.",

keywords = "Lung disease, Population characteristics, Population health, Public health",

author = "Sneha Thatipelli and Kershaw, {Kiarri N.} and Colangelo, {Laura A.} and Penny Gordon-Larsen and Jacobs, {David R.} and Dransfield, {Mark T.} and Daniel Meza and Rosenberg, {Sharon R.} and Washko, {George R.} and Parekh, {Trisha M.} and Carnethon, {Mercedes R.} and Ravi Kalhan",

note = "Publisher Copyright: {\textcopyright} 2021 Elsevier Inc.",

year = "2022",

month = feb,

doi = "10.1016/j.amjmed.2021.07.048",

language = "English (US)",

volume = "135",

pages = "211--218.e1",

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Thatipelli, S, Kershaw, KN, Colangelo, LA, Gordon-Larsen, P, Jacobs, DR, Dransfield, MT, Meza, D , Rosenberg, SR, Washko, GR, Parekh, TM, Carnethon, MR & Kalhan, R 2022, 'Neighborhood Socioeconomic Deprivation in Young Adulthood and Future Respiratory Health: The CARDIA Lung Study', American journal of medicine, vol. 135, no. 2, pp. 211-218.e1. https://doi.org/10.1016/j.amjmed.2021.07.048

TY - JOUR

T1 - Neighborhood Socioeconomic Deprivation in Young Adulthood and Future Respiratory Health

T2 - The CARDIA Lung Study

AU - Thatipelli, Sneha

AU - Kershaw, Kiarri N.

AU - Colangelo, Laura A.

AU - Gordon-Larsen, Penny

AU - Jacobs, David R.

AU - Dransfield, Mark T.

AU - Meza, Daniel

AU - Rosenberg, Sharon R.

AU - Washko, George R.

AU - Parekh, Trisha M.

AU - Carnethon, Mercedes R.

AU - Kalhan, Ravi

PY - 2022/2

Y1 - 2022/2

N2 - Purpose: There are limited data on the relationship between neighborhood level factors and their association with lung health independent of individual socioeconomic status. We sought to determine whether baseline neighborhood level socioeconomic deprivation in young adults is associated with greater 20-year decline in lung function and higher risk of future lung disease, independent of baseline individual income, education, and smoking status. Methods: This multicenter population-based cohort study included 2689 participants in Coronary Artery Risk Development in Young Adults (CARDIA) for whom neighborhood deprivation was determined at year 10 (baseline for study) and who had complete lung function measurements at years 10 and 30. Baseline neighborhood deprivation was defined using 1990 Census blocks as a combination of 4 factors involving median household income, poverty level, and educational achievement. The outcomes were decline in lung function over 20 years (year 10 to 30) and odds of emphysema (year 25). Results: In multivariable regression models, greater baseline neighborhood deprivation was associated with greater decline in lung function (−2.34 mL/year excess annual decline in forced expiratory volume in 1 second (FEV1) in the highest versus lowest deprivation quartile (P =.014)). Furthermore, baseline neighborhood deprivation was independently associated with greater odds of emphysema (odds ratio [OR] 2.99, 95% confidence interval [CI] 1.42-6.30). Conclusions: Residence in neighborhoods with greater socioeconomic deprivation in young adulthood, independent of individual income and smoking, is associated with greater 20-year decline in forced expiratory volume in 1 second and higher risk of future emphysema.

AB - Purpose: There are limited data on the relationship between neighborhood level factors and their association with lung health independent of individual socioeconomic status. We sought to determine whether baseline neighborhood level socioeconomic deprivation in young adults is associated with greater 20-year decline in lung function and higher risk of future lung disease, independent of baseline individual income, education, and smoking status. Methods: This multicenter population-based cohort study included 2689 participants in Coronary Artery Risk Development in Young Adults (CARDIA) for whom neighborhood deprivation was determined at year 10 (baseline for study) and who had complete lung function measurements at years 10 and 30. Baseline neighborhood deprivation was defined using 1990 Census blocks as a combination of 4 factors involving median household income, poverty level, and educational achievement. The outcomes were decline in lung function over 20 years (year 10 to 30) and odds of emphysema (year 25). Results: In multivariable regression models, greater baseline neighborhood deprivation was associated with greater decline in lung function (−2.34 mL/year excess annual decline in forced expiratory volume in 1 second (FEV1) in the highest versus lowest deprivation quartile (P =.014)). Furthermore, baseline neighborhood deprivation was independently associated with greater odds of emphysema (odds ratio [OR] 2.99, 95% confidence interval [CI] 1.42-6.30). Conclusions: Residence in neighborhoods with greater socioeconomic deprivation in young adulthood, independent of individual income and smoking, is associated with greater 20-year decline in forced expiratory volume in 1 second and higher risk of future emphysema.

KW - Lung disease

KW - Population characteristics

KW - Population health

KW - Public health

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ER -

Neighborhood Socioeconomic Deprivation in Young Adulthood and Future Respiratory Health: The CARDIA Lung Study

Abstract

Funding

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ASJC Scopus subject areas

UN SDGs

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