Neo-aortic valvar function after the arterial switch

Bradley S. Marino*, Gil Wernovsky, Doff B. McElhinney, Abbas Jawad, Dieuwertje L. Kreb, Suzan F. Mantel, Wendy L. van der Woerd, Danielle Robbers-Visser, Rita Novello, J. William Gaynor, Thomas L. Spray, Meryl S. Cohen

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

58 Scopus citations


Objectives: The purpose of our study was to assess the prevalence and progression, during childhood and adolescence, of dilation of the neo-aortic root, and neo-aortic valvar regurgitation, and to identify risk factors for such dilation and regurgitation, after the arterial switch operation. Methods: We included all patients who had undergone an arterial switch operation at The Children's Hospital of Philadelphia, and had been followed for a minimum of 4 years, and had at least 2 postoperative echocardiograms. Neo-aortic valvar regurgitation was quantitatively assessed, and measurements were made of the neo-aortic root at the level of the basal attachment of the leaflets, mid-sinusal level, and the sinutubular junction. Results: We found 82 patients who satisfied the criterions for inclusion, of whom 52 patients had transposition with an intact ventricular septum, and 30 had either an associated ventricular septal defect or double outlet right ventricle. The median follow-up time was 8.8 years (4.1 to 16.4 years). The neo-aortic valve had been replaced in 1 patient. Of the patients, 3 had moderate, 66 had trivial to mild, and 12 had no neo-aortic valvar regurgitation at their most recent follow-up. The regurgitation had progressed by at least 1 grade in 38 of the 82 patients (46.4%). Neo-aortic dilation was noted at the basal attachment of the leaflets, and at mid-sinusal level, which was out of proportion to somatic growth. Conclusions: At mid-term follow-up, significant neo-aortic valve regurgitation is present in 3.7%, and trivial to mild regurgitation in 81.4%; of patients. The regurgitation progressed in almost half of the patients over time. We also noted progressive dilation of the neo-aortic root out of proportion to somatic growth.

Original languageEnglish (US)
Pages (from-to)481-489
Number of pages9
JournalCardiology in the young
Issue number5
StatePublished - Oct 1 2006


  • Discordant ventriculo-arterial connections
  • Neo-aortic insufficiency
  • Transposition of the great arteries

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Cardiology and Cardiovascular Medicine

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