Neoadjuvant use of sunitinib in locally advanced GIST with intolerance to imatinib

Jana Svetlichnaya, Timothy K. Huyck, Jeffrey D Wayne, Mark Agulnik*

*Corresponding author for this work

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Gastrointestinal stromal tumors (GIST) arise from precursor cells in the myenteric plexus and comprise the most common mesenchymal tumors of the gastrointestinal tract. Surgical resection is the mainstay of therapy for localized disease. Recurrent, unresectable, and metastatic tumors are associated with a poor prognosis given their resistance to conventional chemotherapy and radiation. Advances in the understanding of molecular pathophysiology of GIST and the use of targeted small-molecule therapies have resulted in dramatic increases in survival. Preliminary data have demonstrated benefits in using imatinib in a neoadjuvant setting; however, there are no studies to date analyzing the use of neoadjuvant sunitinib in primary advanced GIST. Here we present the case of a patient with locally advanced primary GIST who developed severe toxicity on imatinib therapy and was successfully treated with sunitinib in the neoadjuvant setting to achieve complete surgical resection.

Original languageEnglish (US)
Pages (from-to)30-33
Number of pages4
JournalChemotherapy
Volume58
Issue number1
DOIs
Publication statusPublished - Mar 1 2012

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Keywords

  • Gastrointestinal stromal tumors
  • Imatinib
  • Sunitinib

ASJC Scopus subject areas

  • Oncology
  • Pharmacology
  • Drug Discovery
  • Pharmacology (medical)
  • Infectious Diseases

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