Neointimal SMC proliferation in experimental vein grafts: possible role of eddy blood flow

Shu Q. Liu, Melodee M. Smith

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Bypass vein grafts, which are commonly used to replace atherosclerotic arteries, are subject to eddy blood flow induced by graft-host diameter mismatch and anastomotic distortions. It has been shown that eddy flow plays a role in focal smooth muscle cell (SMC) proliferation and intimal hyperplasia, pathological events leading to vein graft restenosis. Thus, it was hypothesized that an elimination of eddy flow may contribute to the prevention of these events. This study was designed to provide experimental evidence for this hypothesis and to achieve the following goals: 1) to show whether eddy flow influenced focal SMC proliferation in the neointima of experimental vein grafts; and 2) to demonstrate whether a mitogenic factor, the angiotensin II type 1 (AT1) receptor, mediated this process.

Original languageEnglish (US)
Title of host publicationAmerican Society of Mechanical Engineers, Bioengineering Division (Publication) BED
PublisherASME
Pages355-356
Number of pages2
Volume42
ISBN (Print)0791816117
StatePublished - Dec 1 1999
Event1999 Bioengineering Conference - Big Sky, MT, USA
Duration: Jun 16 1999Jun 20 1999

Other

Other1999 Bioengineering Conference
CityBig Sky, MT, USA
Period6/16/996/20/99

ASJC Scopus subject areas

  • Engineering(all)

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