Neonatal handling selectively alters the phosphorylation of a 47,000 mol. wt. protein in male rat hippocampus

Scott Cain, Aryeh Routtenberg*

*Corresponding author for this work

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Beginning on postnatal day 1, rat pups were handled for 7 min daily for 23-30 days. This treatment diminished the in vitro phosphorylation of phosphoprotein F-1 [mol. wt. ≈ 47 K daltons, protein B-5014,15] in the hippocampus of male rats. Other major phosphoproteins (D-1-2, mol. wt. 80-86 K daltons; E-2-3, mol. wt. 50-55 K daltons) were not influenced by handling. These findings confirm and extend the results of Holmes et al.5 who observed a decrease in ECS-induced protein kinase activity subsequent to handling.

Original languageEnglish (US)
Pages (from-to)192-195
Number of pages4
JournalBrain research
Volume267
Issue number1
DOIs
StatePublished - May 9 1983

Keywords

  • hippocampus
  • neonatal handling
  • protein phosphorylation

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

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