Neonatal handling selectively alters the phosphorylation of a 47,000 mol. wt. protein in male rat hippocampus

Scott Cain; Aryeh Routtenberg

doi:10.1016/0006-8993(83)91058-2

Neonatal handling selectively alters the phosphorylation of a 47,000 mol. wt. protein in male rat hippocampus

Scott Cain, Aryeh Routtenberg^*

^*Corresponding author for this work

Psychology

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Beginning on postnatal day 1, rat pups were handled for 7 min daily for 23-30 days. This treatment diminished the in vitro phosphorylation of phosphoprotein F-1 [mol. wt. ≈ 47 K daltons, protein B-50^14,15] in the hippocampus of male rats. Other major phosphoproteins (D-1-2, mol. wt. 80-86 K daltons; E-2-3, mol. wt. 50-55 K daltons) were not influenced by handling. These findings confirm and extend the results of Holmes et al.⁵ who observed a decrease in ECS-induced protein kinase activity subsequent to handling.

Original language	English (US)
Pages (from-to)	192-195
Number of pages	4
Journal	Brain research
Volume	267
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(83)91058-2
State	Published - May 9 1983

Keywords

hippocampus
neonatal handling
protein phosphorylation

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(83)91058-2

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title = "Neonatal handling selectively alters the phosphorylation of a 47,000 mol. wt. protein in male rat hippocampus",

abstract = "Beginning on postnatal day 1, rat pups were handled for 7 min daily for 23-30 days. This treatment diminished the in vitro phosphorylation of phosphoprotein F-1 [mol. wt. ≈ 47 K daltons, protein B-5014,15] in the hippocampus of male rats. Other major phosphoproteins (D-1-2, mol. wt. 80-86 K daltons; E-2-3, mol. wt. 50-55 K daltons) were not influenced by handling. These findings confirm and extend the results of Holmes et al.5 who observed a decrease in ECS-induced protein kinase activity subsequent to handling.",

keywords = "hippocampus, neonatal handling, protein phosphorylation",

author = "Scott Cain and Aryeh Routtenberg",

note = "Funding Information: This work was supported by a grant from the National Institute of Mental Health (NIMH 25281) to A.R.",

year = "1983",

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doi = "10.1016/0006-8993(83)91058-2",

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T1 - Neonatal handling selectively alters the phosphorylation of a 47,000 mol. wt. protein in male rat hippocampus

AU - Cain, Scott

AU - Routtenberg, Aryeh

N1 - Funding Information: This work was supported by a grant from the National Institute of Mental Health (NIMH 25281) to A.R.

PY - 1983/5/9

Y1 - 1983/5/9

N2 - Beginning on postnatal day 1, rat pups were handled for 7 min daily for 23-30 days. This treatment diminished the in vitro phosphorylation of phosphoprotein F-1 [mol. wt. ≈ 47 K daltons, protein B-5014,15] in the hippocampus of male rats. Other major phosphoproteins (D-1-2, mol. wt. 80-86 K daltons; E-2-3, mol. wt. 50-55 K daltons) were not influenced by handling. These findings confirm and extend the results of Holmes et al.5 who observed a decrease in ECS-induced protein kinase activity subsequent to handling.

AB - Beginning on postnatal day 1, rat pups were handled for 7 min daily for 23-30 days. This treatment diminished the in vitro phosphorylation of phosphoprotein F-1 [mol. wt. ≈ 47 K daltons, protein B-5014,15] in the hippocampus of male rats. Other major phosphoproteins (D-1-2, mol. wt. 80-86 K daltons; E-2-3, mol. wt. 50-55 K daltons) were not influenced by handling. These findings confirm and extend the results of Holmes et al.5 who observed a decrease in ECS-induced protein kinase activity subsequent to handling.

KW - hippocampus

KW - neonatal handling

KW - protein phosphorylation

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Neonatal handling selectively alters the phosphorylation of a 47,000 mol. wt. protein in male rat hippocampus

Abstract

Keywords

ASJC Scopus subject areas

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