Neonatal hemochromatosis

Amy G. Feldman*, Peter F. Whitington

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

77 Scopus citations


Neonatal hemochromatosis is a clinical condition in which severe liver disease in the newborn is accompanied by extrahepatic siderosis. Gestational alloimmune liver disease (GALD) has been established as the cause of fetal liver injury resulting in nearly all cases of NH. In GALD, a women is exposed to a fetal antigen that she does not recognize as "self" and subsequently begins to produce IgG antibodies that are directed against fetal hepatocytes. These antibodies bind to fetal liver antigen and activate the terminal complement cascade resulting in hepatocyte injury and death. GALD can cause congenital cirrhosis or acute liver failure with and without iron overload and siderosis. Practitioners should consider GALD in cases of fetal demise, stillbirth, and neonatal acute liver failure. Identification of infants with GALD is important as treatment is available and effective for subsequent pregnancies.

Original languageEnglish (US)
Pages (from-to)313-320
Number of pages8
JournalJournal of Clinical and Experimental Hepatology
Issue number4
StatePublished - Dec 2013


  • Acute liver failure
  • Complement
  • Gestational alloimmune liver disease
  • Immunoglobulin

ASJC Scopus subject areas

  • Hepatology


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