Neonatal hemochromatosis

A. S. Knisely, Giorgina Mieli-Vergani, Peter F. Whitington*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

95 Scopus citations

Abstract

Neonatal hemochromatosis is a rare gestational condition in which iron accumulates in the fetal tissues in a distribution like that seen in hereditary hemochromatosis. Extensive liver damage is the dominant clinical feature, with late fetal loss or early neonatal death. NH recurs within sibships at a rate higher than that predicted for simple Mendelian autosomal-recessive inheritance, possibly suggesting the role of a maternal factor. Immunomodulation during pregnancy at risk appears to lessen the severity of disease.

Original languageEnglish (US)
Pages (from-to)877-889
Number of pages13
JournalGastroenterology Clinics of North America
Volume32
Issue number3
DOIs
StatePublished - Sep 2003

ASJC Scopus subject areas

  • Gastroenterology

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