TY - JOUR
T1 - Neonatal hemochromatosis
AU - Knisely, A. S.
AU - Mieli-Vergani, Giorgina
AU - Whitington, Peter F.
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2003/9
Y1 - 2003/9
N2 - Neonatal hemochromatosis is a rare gestational condition in which iron accumulates in the fetal tissues in a distribution like that seen in hereditary hemochromatosis. Extensive liver damage is the dominant clinical feature, with late fetal loss or early neonatal death. NH recurs within sibships at a rate higher than that predicted for simple Mendelian autosomal-recessive inheritance, possibly suggesting the role of a maternal factor. Immunomodulation during pregnancy at risk appears to lessen the severity of disease.
AB - Neonatal hemochromatosis is a rare gestational condition in which iron accumulates in the fetal tissues in a distribution like that seen in hereditary hemochromatosis. Extensive liver damage is the dominant clinical feature, with late fetal loss or early neonatal death. NH recurs within sibships at a rate higher than that predicted for simple Mendelian autosomal-recessive inheritance, possibly suggesting the role of a maternal factor. Immunomodulation during pregnancy at risk appears to lessen the severity of disease.
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U2 - 10.1016/S0889-8553(03)00050-5
DO - 10.1016/S0889-8553(03)00050-5
M3 - Review article
C2 - 14562579
AN - SCOPUS:0141459610
VL - 32
SP - 877
EP - 889
JO - Gastroenterology Clinics of North America
JF - Gastroenterology Clinics of North America
SN - 0889-8553
IS - 3
ER -