Neonatal hemochromatosis

A. S. Knisely; Giorgina Mieli-Vergani; Peter F. Whitington

doi:10.1016/S0889-8553(03)00050-5

Neonatal hemochromatosis

A. S. Knisely, Giorgina Mieli-Vergani, Peter F. Whitington^*

^*Corresponding author for this work

Pediatrics

Research output: Contribution to journal › Review article › peer-review

95 Scopus citations

Abstract

Neonatal hemochromatosis is a rare gestational condition in which iron accumulates in the fetal tissues in a distribution like that seen in hereditary hemochromatosis. Extensive liver damage is the dominant clinical feature, with late fetal loss or early neonatal death. NH recurs within sibships at a rate higher than that predicted for simple Mendelian autosomal-recessive inheritance, possibly suggesting the role of a maternal factor. Immunomodulation during pregnancy at risk appears to lessen the severity of disease.

Original language	English (US)
Pages (from-to)	877-889
Number of pages	13
Journal	Gastroenterology Clinics of North America
Volume	32
Issue number	3
DOIs	https://doi.org/10.1016/S0889-8553(03)00050-5
State	Published - Sep 2003

ASJC Scopus subject areas

Gastroenterology

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N2 - Neonatal hemochromatosis is a rare gestational condition in which iron accumulates in the fetal tissues in a distribution like that seen in hereditary hemochromatosis. Extensive liver damage is the dominant clinical feature, with late fetal loss or early neonatal death. NH recurs within sibships at a rate higher than that predicted for simple Mendelian autosomal-recessive inheritance, possibly suggesting the role of a maternal factor. Immunomodulation during pregnancy at risk appears to lessen the severity of disease.

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